The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

Protein phosphatase 2A (PP2A) activity can be enhanced pharmacologically by PP2A-activating drugs (PADs). The sphingosine analog FTY720 is the best known PAD and we have shown that FTY720 represses production of pro-inflammatory cytokines responsible for respiratory disease pathogenesis. Whether its...

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Detalles Bibliográficos
Autores principales: Rahman, Md. Mostafizur, Prünte, Laura, Lebender, Leonard F., Patel, Brijeshkumar S., Gelissen, Ingrid, Hansbro, Philip M., Morris, Jonathan C., Clark, Andrew R., Verrills, Nicole M., Ammit, Alaina J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110966/
https://www.ncbi.nlm.nih.gov/pubmed/27849062
http://dx.doi.org/10.1038/srep37297

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