Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol

Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, long-term spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for...

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Autores principales: Barrientos, Ruth M., Kitt, Meagan M., D'Angelo, Heather M., Watkins, Linda R., Rudy, Jerry W., Maier, Steven F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110982/
https://www.ncbi.nlm.nih.gov/pubmed/27918274
http://dx.doi.org/10.1101/lm.043489.116
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author Barrientos, Ruth M.
Kitt, Meagan M.
D'Angelo, Heather M.
Watkins, Linda R.
Rudy, Jerry W.
Maier, Steven F.
author_facet Barrientos, Ruth M.
Kitt, Meagan M.
D'Angelo, Heather M.
Watkins, Linda R.
Rudy, Jerry W.
Maier, Steven F.
author_sort Barrientos, Ruth M.
collection PubMed
description Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, long-term spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for the platform 1 and 4 d after training, in both age groups. A 1 h ISI protocol did not produce good retention. Also, compressing the trials into just two sessions separated by a 2.5 h ISI produced limited retention in only young rats.
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spelling pubmed-51109822017-12-01 Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol Barrientos, Ruth M. Kitt, Meagan M. D'Angelo, Heather M. Watkins, Linda R. Rudy, Jerry W. Maier, Steven F. Learn Mem Brief Communication Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, long-term spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for the platform 1 and 4 d after training, in both age groups. A 1 h ISI protocol did not produce good retention. Also, compressing the trials into just two sessions separated by a 2.5 h ISI produced limited retention in only young rats. Cold Spring Harbor Laboratory Press 2016-12 /pmc/articles/PMC5110982/ /pubmed/27918274 http://dx.doi.org/10.1101/lm.043489.116 Text en © 2016 Barrientos et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Barrientos, Ruth M.
Kitt, Meagan M.
D'Angelo, Heather M.
Watkins, Linda R.
Rudy, Jerry W.
Maier, Steven F.
Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
title Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
title_full Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
title_fullStr Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
title_full_unstemmed Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
title_short Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
title_sort stable, long-term, spatial memory in young and aged rats achieved with a one day morris water maze training protocol
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110982/
https://www.ncbi.nlm.nih.gov/pubmed/27918274
http://dx.doi.org/10.1101/lm.043489.116
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