Genomic profiling of multiple sequentially acquired tumor metastatic sites from an “exceptional responder” lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response

We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an “exceptional responder” lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alteratio...

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Detalles Bibliográficos
Autores principales: Biswas, Romi, Gao, Shaojian, Cultraro, Constance M., Maity, Tapan K., Venugopalan, Abhilash, Abdullaev, Zied, Shaytan, Alexey K., Carter, Corey A., Thomas, Anish, Rajan, Arun, Song, Young, Pitts, Stephanie, Chen, Kevin, Bass, Sara, Boland, Joseph, Hanada, Ken-Ichi, Chen, Jinqiu, Meltzer, Paul S., Panchenko, Anna R., Yang, James C., Pack, Svetlana, Giaccone, Giuseppe, Schrump, David S., Khan, Javed, Guha, Udayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111000/
https://www.ncbi.nlm.nih.gov/pubmed/27900369
http://dx.doi.org/10.1101/mcs.a001263

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