Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profi...

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Detalles Bibliográficos
Autores principales: Gröschel, Stefan, Bommer, Martin, Hutter, Barbara, Budczies, Jan, Bonekamp, David, Heining, Christoph, Horak, Peter, Fröhlich, Martina, Uhrig, Sebastian, Hübschmann, Daniel, Geörg, Christina, Richter, Daniela, Pfarr, Nicole, Pfütze, Katrin, Wolf, Stephan, Schirmacher, Peter, Jäger, Dirk, von Kalle, Christof, Brors, Benedikt, Glimm, Hanno, Weichert, Wilko, Stenzinger, Albrecht, Fröhling, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111004/
https://www.ncbi.nlm.nih.gov/pubmed/27900363
http://dx.doi.org/10.1101/mcs.a001180

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