Modulation of NMDA channel gating by Ca(2+) and Cd(2+) binding to the external pore mouth

NMDA receptor channels are characterized by high Ca(2+) permeability. It remains unclear whether extracellular Ca(2+) could directly modulate channel gating and control Ca(2+) influxes. We demonstrate a pore-blocking site external to the activation gate for extracellular Ca(2+) and Cd(2+), which has...

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Detalles Bibliográficos
Autores principales: Tu, Ya-Chi, Yang, Ya-Chin, Kuo, Chung-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111045/
https://www.ncbi.nlm.nih.gov/pubmed/27848984
http://dx.doi.org/10.1038/srep37029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111045/
https://www.ncbi.nlm.nih.gov/pubmed/27848984
http://dx.doi.org/10.1038/srep37029

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