Cargando…
Modulation of NMDA channel gating by Ca(2+) and Cd(2+) binding to the external pore mouth
NMDA receptor channels are characterized by high Ca(2+) permeability. It remains unclear whether extracellular Ca(2+) could directly modulate channel gating and control Ca(2+) influxes. We demonstrate a pore-blocking site external to the activation gate for extracellular Ca(2+) and Cd(2+), which has...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111045/ https://www.ncbi.nlm.nih.gov/pubmed/27848984 http://dx.doi.org/10.1038/srep37029 |