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Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells

Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through t...

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Autores principales: Ishihara, Kazuhiko, Chen, Weixin, Liu, Yihua, Tsukamoto, Yuriko, Inoue, Yuuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111563/
https://www.ncbi.nlm.nih.gov/pubmed/27877883
http://dx.doi.org/10.1080/14686996.2016.1190257
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author Ishihara, Kazuhiko
Chen, Weixin
Liu, Yihua
Tsukamoto, Yuriko
Inoue, Yuuki
author_facet Ishihara, Kazuhiko
Chen, Weixin
Liu, Yihua
Tsukamoto, Yuriko
Inoue, Yuuki
author_sort Ishihara, Kazuhiko
collection PubMed
description Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an artificial cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the artificial cell membrane structure, and their performance as in-cell devices; and finally, it evaluates both their chemical reactivity and effects in cells.
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spelling pubmed-51115632016-11-22 Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells Ishihara, Kazuhiko Chen, Weixin Liu, Yihua Tsukamoto, Yuriko Inoue, Yuuki Sci Technol Adv Mater Focus on Nanomedicine Molecular Science Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an artificial cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the artificial cell membrane structure, and their performance as in-cell devices; and finally, it evaluates both their chemical reactivity and effects in cells. Taylor & Francis 2016-07-06 /pmc/articles/PMC5111563/ /pubmed/27877883 http://dx.doi.org/10.1080/14686996.2016.1190257 Text en © 2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License CC-BYhttp://creativecommons.org/licenses/by/4.0/which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Focus on Nanomedicine Molecular Science
Ishihara, Kazuhiko
Chen, Weixin
Liu, Yihua
Tsukamoto, Yuriko
Inoue, Yuuki
Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
title Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
title_full Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
title_fullStr Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
title_full_unstemmed Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
title_short Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
title_sort cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
topic Focus on Nanomedicine Molecular Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111563/
https://www.ncbi.nlm.nih.gov/pubmed/27877883
http://dx.doi.org/10.1080/14686996.2016.1190257
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