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Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells
Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111563/ https://www.ncbi.nlm.nih.gov/pubmed/27877883 http://dx.doi.org/10.1080/14686996.2016.1190257 |
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author | Ishihara, Kazuhiko Chen, Weixin Liu, Yihua Tsukamoto, Yuriko Inoue, Yuuki |
author_facet | Ishihara, Kazuhiko Chen, Weixin Liu, Yihua Tsukamoto, Yuriko Inoue, Yuuki |
author_sort | Ishihara, Kazuhiko |
collection | PubMed |
description | Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an artificial cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the artificial cell membrane structure, and their performance as in-cell devices; and finally, it evaluates both their chemical reactivity and effects in cells. |
format | Online Article Text |
id | pubmed-5111563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-51115632016-11-22 Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells Ishihara, Kazuhiko Chen, Weixin Liu, Yihua Tsukamoto, Yuriko Inoue, Yuuki Sci Technol Adv Mater Focus on Nanomedicine Molecular Science Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an artificial cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the artificial cell membrane structure, and their performance as in-cell devices; and finally, it evaluates both their chemical reactivity and effects in cells. Taylor & Francis 2016-07-06 /pmc/articles/PMC5111563/ /pubmed/27877883 http://dx.doi.org/10.1080/14686996.2016.1190257 Text en © 2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License CC-BYhttp://creativecommons.org/licenses/by/4.0/which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Focus on Nanomedicine Molecular Science Ishihara, Kazuhiko Chen, Weixin Liu, Yihua Tsukamoto, Yuriko Inoue, Yuuki Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
title | Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
title_full | Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
title_fullStr | Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
title_full_unstemmed | Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
title_short | Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
title_sort | cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells |
topic | Focus on Nanomedicine Molecular Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111563/ https://www.ncbi.nlm.nih.gov/pubmed/27877883 http://dx.doi.org/10.1080/14686996.2016.1190257 |
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