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AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance

Type 2 diabetes is characterized by triglyceride accumulation and reduced lipid oxidation capacity in skeletal muscle. SIRT1 is a key protein in the regulation of lipid oxidation and its expression is reduced in the skeletal muscle of insulin resistant mice. In this tissue, Sirt1 up-regulates the ex...

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Detalles Bibliográficos
Autores principales:	Vilà, Laia, Roca, Carles, Elias, Ivet, Casellas, Alba, Lage, Ricardo, Franckhauser, Sylvie, Bosch, Fatima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111573/ https://www.ncbi.nlm.nih.gov/pubmed/27909699 http://dx.doi.org/10.1038/mtm.2016.72

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