Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies

The systemic delivery of therapeutic viruses, such as oncolytic viruses or vaccines, is limited by the generation of neutralizing antibodies. While pseudotyping of rhabdoviruses with the lymphocytic choriomeningitis virus glycoprotein has previously allowed for multiple rounds of delivery in mice, t...

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Detalles Bibliográficos
Autores principales: Evgin, Laura, Ilkow, Carolina S, Bourgeois-Daigneault, Marie-Claude, de Souza, Christiano Tanese, Stubbert, Lawton, Huh, Michael S, Jennings, Victoria A, Marguerie, Monique, Acuna, Sergio A, Keller, Brian A, Lefebvre, Charles, Falls, Theresa, Le Boeuf, Fabrice, Auer, Rebecca A, Lambris, John D, McCart, J Andrea, Stojdl, David F, Bell, John C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111574/
https://www.ncbi.nlm.nih.gov/pubmed/27909702
http://dx.doi.org/10.1038/mto.2016.27

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