Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer

The engineered Salmonella typhimurium ΔppGpp (S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combi...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiande, Jiang, Shengnan, Piao, Linghua, Yuan, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2016
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111844/
https://www.ncbi.nlm.nih.gov/pubmed/27301721
http://dx.doi.org/10.1538/expanim.16-0033
_version_ 1782467915700764672
author Liu, Xiande
Jiang, Shengnan
Piao, Linghua
Yuan, Feng
author_facet Liu, Xiande
Jiang, Shengnan
Piao, Linghua
Yuan, Feng
author_sort Liu, Xiande
collection PubMed
description The engineered Salmonella typhimurium ΔppGpp (S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combined with radiotherapy using the attenuated strain S.t ΔppGpp/pBAD-ClyA. Radiotherapy (21Gy) contributed to S. typhimurium colonization in a colon tumor (CT26) model of BALB/c mice. The combination of bacterial therapy and radiotherapy treatments reduced tumor growth compared with only bacterial therapy.
format Online
Article
Text
id pubmed-5111844
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Japanese Association for Laboratory Animal Science
record_format MEDLINE/PubMed
spelling pubmed-51118442016-11-17 Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer Liu, Xiande Jiang, Shengnan Piao, Linghua Yuan, Feng Exp Anim Original The engineered Salmonella typhimurium ΔppGpp (S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combined with radiotherapy using the attenuated strain S.t ΔppGpp/pBAD-ClyA. Radiotherapy (21Gy) contributed to S. typhimurium colonization in a colon tumor (CT26) model of BALB/c mice. The combination of bacterial therapy and radiotherapy treatments reduced tumor growth compared with only bacterial therapy. Japanese Association for Laboratory Animal Science 2016-06-10 2016 /pmc/articles/PMC5111844/ /pubmed/27301721 http://dx.doi.org/10.1538/expanim.16-0033 Text en ©2016 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Liu, Xiande
Jiang, Shengnan
Piao, Linghua
Yuan, Feng
Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
title Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
title_full Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
title_fullStr Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
title_full_unstemmed Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
title_short Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
title_sort radiotherapy combined with an engineered salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111844/
https://www.ncbi.nlm.nih.gov/pubmed/27301721
http://dx.doi.org/10.1538/expanim.16-0033
work_keys_str_mv AT liuxiande radiotherapycombinedwithanengineeredsalmonellatyphimuriuminhibitstumorgrowthinamousemodelofcoloncancer
AT jiangshengnan radiotherapycombinedwithanengineeredsalmonellatyphimuriuminhibitstumorgrowthinamousemodelofcoloncancer
AT piaolinghua radiotherapycombinedwithanengineeredsalmonellatyphimuriuminhibitstumorgrowthinamousemodelofcoloncancer
AT yuanfeng radiotherapycombinedwithanengineeredsalmonellatyphimuriuminhibitstumorgrowthinamousemodelofcoloncancer

Ejemplares similares