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Herpes zoster correlates with pyogenic liver abscesses in Taiwan

OBJECTIVE: The purpose of the paper was to explore the relationship between herpes zoster and pyogenic liver abscesses in Taiwan. METHODS: This was a nationwide cohort study. Using the database of the Taiwan National Health Insurance Program, there were 33049 subjects aged 20-84 years who were newly...

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Autores principales: Mei-Ling, Shen, Kuan-Fu, Liao, Sung-Mao, Tsai, Cheng-Li, Lin MS, Shih-Wei, Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Medical University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112182/
https://www.ncbi.nlm.nih.gov/pubmed/27854050
http://dx.doi.org/10.7603/s40681-016-0022-4
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author Mei-Ling, Shen
Kuan-Fu, Liao
Sung-Mao, Tsai
Cheng-Li, Lin MS
Shih-Wei, Lai
author_facet Mei-Ling, Shen
Kuan-Fu, Liao
Sung-Mao, Tsai
Cheng-Li, Lin MS
Shih-Wei, Lai
author_sort Mei-Ling, Shen
collection PubMed
description OBJECTIVE: The purpose of the paper was to explore the relationship between herpes zoster and pyogenic liver abscesses in Taiwan. METHODS: This was a nationwide cohort study. Using the database of the Taiwan National Health Insurance Program, there were 33049 subjects aged 20-84 years who were newly diagnosed with herpes zoster from 1998 to 2010 that were selected for our study, and they were our herpes zoster group. 131707 randomly selected subjects without herpes zoster were our non-herpes zoster group. Both groups were matched by sex, age, other comorbidities, and the index year of their herpes zoster diagnosis. The incidence of pyogenic liver abscesses at the end of 2011 was then estimated. The multivariable Cox proportional hazard regression model was used to estimate the hazard ratio and 95% confidence interval for pyogenic liver abscesses associated with herpes zoster and other comorbidities. RESULTS: The overall incidence rate was 1.38-fold higher in the herpes zoster group than in the non-herpes zoster group (4.47 vs. 3.25 per 10000 person-years, 95% confidence interval 1.32, 1.44). After controlling for potential confounding factors, the adjusted hazard ratio of pyogenic liver abscesses was 1.34 in the herpes zoster group (95% confidence interval 1.05, 1.72) when compared with the non-herpes zoster group. Sex (in this case male), age, presence of biliary stones, chronic kidney diseases, chronic liver diseases, cancers, and diabetes mellitus were also significantly associated with pyogenic liver abscesses. CONCLUSIONS: Patients with herpes zoster are associated with an increased hazard of developing pyogenic liver abscesses.
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spelling pubmed-51121822016-11-29 Herpes zoster correlates with pyogenic liver abscesses in Taiwan Mei-Ling, Shen Kuan-Fu, Liao Sung-Mao, Tsai Cheng-Li, Lin MS Shih-Wei, Lai Biomedicine (Taipei) Original Article OBJECTIVE: The purpose of the paper was to explore the relationship between herpes zoster and pyogenic liver abscesses in Taiwan. METHODS: This was a nationwide cohort study. Using the database of the Taiwan National Health Insurance Program, there were 33049 subjects aged 20-84 years who were newly diagnosed with herpes zoster from 1998 to 2010 that were selected for our study, and they were our herpes zoster group. 131707 randomly selected subjects without herpes zoster were our non-herpes zoster group. Both groups were matched by sex, age, other comorbidities, and the index year of their herpes zoster diagnosis. The incidence of pyogenic liver abscesses at the end of 2011 was then estimated. The multivariable Cox proportional hazard regression model was used to estimate the hazard ratio and 95% confidence interval for pyogenic liver abscesses associated with herpes zoster and other comorbidities. RESULTS: The overall incidence rate was 1.38-fold higher in the herpes zoster group than in the non-herpes zoster group (4.47 vs. 3.25 per 10000 person-years, 95% confidence interval 1.32, 1.44). After controlling for potential confounding factors, the adjusted hazard ratio of pyogenic liver abscesses was 1.34 in the herpes zoster group (95% confidence interval 1.05, 1.72) when compared with the non-herpes zoster group. Sex (in this case male), age, presence of biliary stones, chronic kidney diseases, chronic liver diseases, cancers, and diabetes mellitus were also significantly associated with pyogenic liver abscesses. CONCLUSIONS: Patients with herpes zoster are associated with an increased hazard of developing pyogenic liver abscesses. China Medical University 2016-11-17 /pmc/articles/PMC5112182/ /pubmed/27854050 http://dx.doi.org/10.7603/s40681-016-0022-4 Text en © China Medical University 2016 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.
spellingShingle Original Article
Mei-Ling, Shen
Kuan-Fu, Liao
Sung-Mao, Tsai
Cheng-Li, Lin MS
Shih-Wei, Lai
Herpes zoster correlates with pyogenic liver abscesses in Taiwan
title Herpes zoster correlates with pyogenic liver abscesses in Taiwan
title_full Herpes zoster correlates with pyogenic liver abscesses in Taiwan
title_fullStr Herpes zoster correlates with pyogenic liver abscesses in Taiwan
title_full_unstemmed Herpes zoster correlates with pyogenic liver abscesses in Taiwan
title_short Herpes zoster correlates with pyogenic liver abscesses in Taiwan
title_sort herpes zoster correlates with pyogenic liver abscesses in taiwan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112182/
https://www.ncbi.nlm.nih.gov/pubmed/27854050
http://dx.doi.org/10.7603/s40681-016-0022-4
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