An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds

TDP-43 is an essential RNA-binding protein forming aggregates in almost all cases of sporadic amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar dementia (FTLD) and other neurodegenerative diseases. TDP-43 consists of a folded N-terminal domain with a singular structure, two...

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Detalles Bibliográficos
Autores principales: Mompeán, Miguel, Baralle, Marco, Buratti, Emanuele, Laurents, Douglas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112254/
https://www.ncbi.nlm.nih.gov/pubmed/27909398
http://dx.doi.org/10.3389/fnmol.2016.00125

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