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Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical graf...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112259/ https://www.ncbi.nlm.nih.gov/pubmed/27909435 http://dx.doi.org/10.3389/fimmu.2016.00507 |
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author | Ogonek, Justyna Kralj Juric, Mateja Ghimire, Sakhila Varanasi, Pavankumar Reddy Holler, Ernst Greinix, Hildegard Weissinger, Eva |
author_facet | Ogonek, Justyna Kralj Juric, Mateja Ghimire, Sakhila Varanasi, Pavankumar Reddy Holler, Ernst Greinix, Hildegard Weissinger, Eva |
author_sort | Ogonek, Justyna |
collection | PubMed |
description | The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures. Immune reconstitution post-HSCT occurs in several phases, innate immunity being the first to regain function. The slow T cell reconstitution is regarded as primarily responsible for deleterious infections with latent viruses or fungi, occurrence of graft-versus-host disease, and relapse. Here we aim to summarize the major steps of the adaptive immune reconstitution and will discuss the importance of immune balance in patients after HSCT. |
format | Online Article Text |
id | pubmed-5112259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51122592016-12-01 Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation Ogonek, Justyna Kralj Juric, Mateja Ghimire, Sakhila Varanasi, Pavankumar Reddy Holler, Ernst Greinix, Hildegard Weissinger, Eva Front Immunol Immunology The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures. Immune reconstitution post-HSCT occurs in several phases, innate immunity being the first to regain function. The slow T cell reconstitution is regarded as primarily responsible for deleterious infections with latent viruses or fungi, occurrence of graft-versus-host disease, and relapse. Here we aim to summarize the major steps of the adaptive immune reconstitution and will discuss the importance of immune balance in patients after HSCT. Frontiers Media S.A. 2016-11-17 /pmc/articles/PMC5112259/ /pubmed/27909435 http://dx.doi.org/10.3389/fimmu.2016.00507 Text en Copyright © 2016 Ogonek, Kralj Juric, Ghimire, Varanasi, Holler, Greinix and Weissinger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ogonek, Justyna Kralj Juric, Mateja Ghimire, Sakhila Varanasi, Pavankumar Reddy Holler, Ernst Greinix, Hildegard Weissinger, Eva Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation |
title | Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation |
title_full | Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation |
title_fullStr | Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation |
title_full_unstemmed | Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation |
title_short | Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation |
title_sort | immune reconstitution after allogeneic hematopoietic stem cell transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112259/ https://www.ncbi.nlm.nih.gov/pubmed/27909435 http://dx.doi.org/10.3389/fimmu.2016.00507 |
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