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Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical graf...

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Autores principales: Ogonek, Justyna, Kralj Juric, Mateja, Ghimire, Sakhila, Varanasi, Pavankumar Reddy, Holler, Ernst, Greinix, Hildegard, Weissinger, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112259/
https://www.ncbi.nlm.nih.gov/pubmed/27909435
http://dx.doi.org/10.3389/fimmu.2016.00507
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author Ogonek, Justyna
Kralj Juric, Mateja
Ghimire, Sakhila
Varanasi, Pavankumar Reddy
Holler, Ernst
Greinix, Hildegard
Weissinger, Eva
author_facet Ogonek, Justyna
Kralj Juric, Mateja
Ghimire, Sakhila
Varanasi, Pavankumar Reddy
Holler, Ernst
Greinix, Hildegard
Weissinger, Eva
author_sort Ogonek, Justyna
collection PubMed
description The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures. Immune reconstitution post-HSCT occurs in several phases, innate immunity being the first to regain function. The slow T cell reconstitution is regarded as primarily responsible for deleterious infections with latent viruses or fungi, occurrence of graft-versus-host disease, and relapse. Here we aim to summarize the major steps of the adaptive immune reconstitution and will discuss the importance of immune balance in patients after HSCT.
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spelling pubmed-51122592016-12-01 Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation Ogonek, Justyna Kralj Juric, Mateja Ghimire, Sakhila Varanasi, Pavankumar Reddy Holler, Ernst Greinix, Hildegard Weissinger, Eva Front Immunol Immunology The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures. Immune reconstitution post-HSCT occurs in several phases, innate immunity being the first to regain function. The slow T cell reconstitution is regarded as primarily responsible for deleterious infections with latent viruses or fungi, occurrence of graft-versus-host disease, and relapse. Here we aim to summarize the major steps of the adaptive immune reconstitution and will discuss the importance of immune balance in patients after HSCT. Frontiers Media S.A. 2016-11-17 /pmc/articles/PMC5112259/ /pubmed/27909435 http://dx.doi.org/10.3389/fimmu.2016.00507 Text en Copyright © 2016 Ogonek, Kralj Juric, Ghimire, Varanasi, Holler, Greinix and Weissinger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ogonek, Justyna
Kralj Juric, Mateja
Ghimire, Sakhila
Varanasi, Pavankumar Reddy
Holler, Ernst
Greinix, Hildegard
Weissinger, Eva
Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
title Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
title_full Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
title_fullStr Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
title_full_unstemmed Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
title_short Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
title_sort immune reconstitution after allogeneic hematopoietic stem cell transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112259/
https://www.ncbi.nlm.nih.gov/pubmed/27909435
http://dx.doi.org/10.3389/fimmu.2016.00507
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