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Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study

OBJECTIVE: To evaluate the safety, feasibility and clinical results of the modified delta-shaped gastroduodenostomy (MDSG) in totally laparoscopic distal gastrectomy (TLDG) for gastric cancer (GC). METHODS: We performed a case–control and case-matched study enrolling 642 patients with GC undergoing...

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Autores principales: Lin, Mi, Zheng, Chao-Hui, Huang, Chang-Ming, Li, Ping, Xie, Jian-Wei, Wang, Jia-Bin, Lin, Jian-Xian, Lu, Jun, Chen, Qi-Yue, Cao, Long-Long, Tu, Ru-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112298/
https://www.ncbi.nlm.nih.gov/pubmed/27008576
http://dx.doi.org/10.1007/s00464-016-4872-3
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author Lin, Mi
Zheng, Chao-Hui
Huang, Chang-Ming
Li, Ping
Xie, Jian-Wei
Wang, Jia-Bin
Lin, Jian-Xian
Lu, Jun
Chen, Qi-Yue
Cao, Long-Long
Tu, Ru-Hong
author_facet Lin, Mi
Zheng, Chao-Hui
Huang, Chang-Ming
Li, Ping
Xie, Jian-Wei
Wang, Jia-Bin
Lin, Jian-Xian
Lu, Jun
Chen, Qi-Yue
Cao, Long-Long
Tu, Ru-Hong
author_sort Lin, Mi
collection PubMed
description OBJECTIVE: To evaluate the safety, feasibility and clinical results of the modified delta-shaped gastroduodenostomy (MDSG) in totally laparoscopic distal gastrectomy (TLDG) for gastric cancer (GC). METHODS: We performed a case–control and case-matched study enrolling 642 patients with GC undergoing laparoscopic distal gastrectomy with Billroth-I anastomosis from January 2011 to December 2014. TLDG with MDSG was performed in 158 patients (Group TL), and laparoscopy-assisted distal gastrectomy with circular anastomosis was performed in 484 patients (Group LA). One-to-one propensity score matching (PSM) was performed to compare the clinicopathological characteristics between the two groups. RESULTS: Patients with smaller tumors or stage I cancer were more likely to receive TLDG (P < 0.05). In the propensity-matched analysis of 143 pairs, there were no differences in demographic and pathologic characteristics between groups (all P < 0.05). All patients successfully underwent laparoscopic radical distal gastrectomy. Before PSM, Group TL had more dissected lymph nodes (LNs), a longer time to first fluid diet and a longer postoperative length of stay than Group LA (all P < 0.05). After PSM, except for the fact that more dissected LNs were obtained in Group LA (P < 0.05), no difference was found in the intraoperative and postoperative outcomes between the groups (all P > 0.05). The postoperative complications were similar in both groups (all P > 0.05). Stratification analysis performed after PSM showed that in early GC, no difference was observed in intraoperative and postoperative outcomes between the groups (all P > 0.05). However, in locally advanced GC, Group TL had more dissected LNs and a higher rate of postoperative complications (both P < 0.05). Univariate analysis carried out in locally advanced cases after PSM showed that the body mass index (BMI), the method of digestive tract reconstruction and Charlson’s score were significant factors that affected postoperative morbidity (all P < 0.05). Multivariate analysis indicated that BMI was an independent risk factor for postoperative morbidity (P < 0.05). CONCLUSIONS: The MDSG in TLDG is safe and feasible for early GC; however, it should be chosen with caution in advanced GC, particularly in patients with a high BMI.
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spelling pubmed-51122982016-11-29 Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study Lin, Mi Zheng, Chao-Hui Huang, Chang-Ming Li, Ping Xie, Jian-Wei Wang, Jia-Bin Lin, Jian-Xian Lu, Jun Chen, Qi-Yue Cao, Long-Long Tu, Ru-Hong Surg Endosc Article OBJECTIVE: To evaluate the safety, feasibility and clinical results of the modified delta-shaped gastroduodenostomy (MDSG) in totally laparoscopic distal gastrectomy (TLDG) for gastric cancer (GC). METHODS: We performed a case–control and case-matched study enrolling 642 patients with GC undergoing laparoscopic distal gastrectomy with Billroth-I anastomosis from January 2011 to December 2014. TLDG with MDSG was performed in 158 patients (Group TL), and laparoscopy-assisted distal gastrectomy with circular anastomosis was performed in 484 patients (Group LA). One-to-one propensity score matching (PSM) was performed to compare the clinicopathological characteristics between the two groups. RESULTS: Patients with smaller tumors or stage I cancer were more likely to receive TLDG (P < 0.05). In the propensity-matched analysis of 143 pairs, there were no differences in demographic and pathologic characteristics between groups (all P < 0.05). All patients successfully underwent laparoscopic radical distal gastrectomy. Before PSM, Group TL had more dissected lymph nodes (LNs), a longer time to first fluid diet and a longer postoperative length of stay than Group LA (all P < 0.05). After PSM, except for the fact that more dissected LNs were obtained in Group LA (P < 0.05), no difference was found in the intraoperative and postoperative outcomes between the groups (all P > 0.05). The postoperative complications were similar in both groups (all P > 0.05). Stratification analysis performed after PSM showed that in early GC, no difference was observed in intraoperative and postoperative outcomes between the groups (all P > 0.05). However, in locally advanced GC, Group TL had more dissected LNs and a higher rate of postoperative complications (both P < 0.05). Univariate analysis carried out in locally advanced cases after PSM showed that the body mass index (BMI), the method of digestive tract reconstruction and Charlson’s score were significant factors that affected postoperative morbidity (all P < 0.05). Multivariate analysis indicated that BMI was an independent risk factor for postoperative morbidity (P < 0.05). CONCLUSIONS: The MDSG in TLDG is safe and feasible for early GC; however, it should be chosen with caution in advanced GC, particularly in patients with a high BMI. Springer US 2016-03-23 2016 /pmc/articles/PMC5112298/ /pubmed/27008576 http://dx.doi.org/10.1007/s00464-016-4872-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Lin, Mi
Zheng, Chao-Hui
Huang, Chang-Ming
Li, Ping
Xie, Jian-Wei
Wang, Jia-Bin
Lin, Jian-Xian
Lu, Jun
Chen, Qi-Yue
Cao, Long-Long
Tu, Ru-Hong
Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study
title Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study
title_full Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study
title_fullStr Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study
title_full_unstemmed Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study
title_short Totally laparoscopic versus laparoscopy-assisted Billroth-I anastomosis for gastric cancer: a case–control and case-matched study
title_sort totally laparoscopic versus laparoscopy-assisted billroth-i anastomosis for gastric cancer: a case–control and case-matched study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112298/
https://www.ncbi.nlm.nih.gov/pubmed/27008576
http://dx.doi.org/10.1007/s00464-016-4872-3
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