Cargando…

Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia

An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by car...

Descripción completa

Detalles Bibliográficos
Autores principales: Ono, Yuko, Shimo, Tsuyoshi, Shirafuji, Yoshinori, Hamada, Toshihisa, Masui, Masanori, Obata, Kyoichi, Yao, Mayumi, Kishimoto, Koji, Sasaki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112318/
https://www.ncbi.nlm.nih.gov/pubmed/27885344
http://dx.doi.org/10.1155/2016/4605231
_version_ 1782467972879613952
author Ono, Yuko
Shimo, Tsuyoshi
Shirafuji, Yoshinori
Hamada, Toshihisa
Masui, Masanori
Obata, Kyoichi
Yao, Mayumi
Kishimoto, Koji
Sasaki, Akira
author_facet Ono, Yuko
Shimo, Tsuyoshi
Shirafuji, Yoshinori
Hamada, Toshihisa
Masui, Masanori
Obata, Kyoichi
Yao, Mayumi
Kishimoto, Koji
Sasaki, Akira
author_sort Ono, Yuko
collection PubMed
description An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared.
format Online
Article
Text
id pubmed-5112318
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-51123182016-11-24 Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia Ono, Yuko Shimo, Tsuyoshi Shirafuji, Yoshinori Hamada, Toshihisa Masui, Masanori Obata, Kyoichi Yao, Mayumi Kishimoto, Koji Sasaki, Akira Case Rep Dent Case Report An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared. Hindawi Publishing Corporation 2016 2016-11-03 /pmc/articles/PMC5112318/ /pubmed/27885344 http://dx.doi.org/10.1155/2016/4605231 Text en Copyright © 2016 Yuko Ono et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ono, Yuko
Shimo, Tsuyoshi
Shirafuji, Yoshinori
Hamada, Toshihisa
Masui, Masanori
Obata, Kyoichi
Yao, Mayumi
Kishimoto, Koji
Sasaki, Akira
Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
title Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
title_full Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
title_fullStr Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
title_full_unstemmed Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
title_short Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
title_sort drug-induced hypersensitivity syndrome caused by carbamazepine used for the treatment of trigeminal neuralgia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112318/
https://www.ncbi.nlm.nih.gov/pubmed/27885344
http://dx.doi.org/10.1155/2016/4605231
work_keys_str_mv AT onoyuko druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT shimotsuyoshi druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT shirafujiyoshinori druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT hamadatoshihisa druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT masuimasanori druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT obatakyoichi druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT yaomayumi druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT kishimotokoji druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia
AT sasakiakira druginducedhypersensitivitysyndromecausedbycarbamazepineusedforthetreatmentoftrigeminalneuralgia