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Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia
An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by car...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112318/ https://www.ncbi.nlm.nih.gov/pubmed/27885344 http://dx.doi.org/10.1155/2016/4605231 |
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author | Ono, Yuko Shimo, Tsuyoshi Shirafuji, Yoshinori Hamada, Toshihisa Masui, Masanori Obata, Kyoichi Yao, Mayumi Kishimoto, Koji Sasaki, Akira |
author_facet | Ono, Yuko Shimo, Tsuyoshi Shirafuji, Yoshinori Hamada, Toshihisa Masui, Masanori Obata, Kyoichi Yao, Mayumi Kishimoto, Koji Sasaki, Akira |
author_sort | Ono, Yuko |
collection | PubMed |
description | An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared. |
format | Online Article Text |
id | pubmed-5112318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51123182016-11-24 Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia Ono, Yuko Shimo, Tsuyoshi Shirafuji, Yoshinori Hamada, Toshihisa Masui, Masanori Obata, Kyoichi Yao, Mayumi Kishimoto, Koji Sasaki, Akira Case Rep Dent Case Report An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared. Hindawi Publishing Corporation 2016 2016-11-03 /pmc/articles/PMC5112318/ /pubmed/27885344 http://dx.doi.org/10.1155/2016/4605231 Text en Copyright © 2016 Yuko Ono et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ono, Yuko Shimo, Tsuyoshi Shirafuji, Yoshinori Hamada, Toshihisa Masui, Masanori Obata, Kyoichi Yao, Mayumi Kishimoto, Koji Sasaki, Akira Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia |
title | Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia |
title_full | Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia |
title_fullStr | Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia |
title_full_unstemmed | Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia |
title_short | Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia |
title_sort | drug-induced hypersensitivity syndrome caused by carbamazepine used for the treatment of trigeminal neuralgia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112318/ https://www.ncbi.nlm.nih.gov/pubmed/27885344 http://dx.doi.org/10.1155/2016/4605231 |
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