Cargando…

Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation

Tissue injury is known to produce inflammation and pain. Synaptic potentiation between peripheral nociceptors and spinal lamina I neurons has been proposed to serve as a trigger for chronic inflammatory pain. Gastrodin is a main bioactive constituent of the traditional Chinese herbal medicine Gastro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Mei-Mei, Zhang, Yu-Qi, Wang, Wen-Ting, Han, Wen-Juan, Lin, Zhen, Xie, Rou-Gang, Cao, Zhi, Lu, Na, Hu, San-Jue, Wu, Sheng-Xi, Dong, Hui, Luo, Ceng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112517/ https://www.ncbi.nlm.nih.gov/pubmed/27853254 http://dx.doi.org/10.1038/srep37251

Ejemplares similares

Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons
por: Sun, Wei, et al.
Publicado: (2012)

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
por: Xie, Rou-Gang, et al.
Publicado: (2022)

Characterization of Different Types of Excitability in Large Somatosensory Neurons and Its Plastic Changes in Pathological Pain States
por: Xie, Rou-Gang, et al.
Publicado: (2018)

CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals
por: Ma, Sui-Bin, et al.
Publicado: (2020)

Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord
por: Song, Changwei, et al.
Publicado: (2013)

Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current (I(h)) in large-diameter dorsal root ganglion neurons
por: Liu, Da-Lu, et al.
Publicado: (2017)

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity
por: Luo, Ceng, et al.
Publicado: (2012)

Presynaptic cGMP-dependent protein kinase-I mediates synaptic potentiation in spinal amplification of pain
por: Luo, Ceng, et al.
Publicado: (2009)

Upregulation of I(h) expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain
por: Liu, Da-Lu, et al.
Publicado: (2015)

Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina II Neurons
por: Zhang, Hui, et al.
Publicado: (2020)

Gastrodin Derivatives from Gastrodia elata
por: Xu, Cheng-Bo, et al.
Publicado: (2019)

Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats
por: Chen, Peng-zhi, et al.
Publicado: (2014)

Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain
por: Wang, Xiangyu, et al.
Publicado: (2021)

Gastrodin exerts protective effects in reactive TNC1 astrocytes via regulation of the Notch signaling pathway
por: Zhang, Xiao Li Na, et al.
Publicado: (2021)

Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain
por: Taves, Sarah, et al.
Publicado: (2013)

Clinical therapeutic effects of gastrodin in combination with betahistine on vertigo: A protocol for systematic review and meta-analysis
por: Qiao, Yu-Lin, et al.
Publicado: (2021)

Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson's Disease Model
por: Kumar, Hemant, et al.
Publicado: (2013)

Gastrodin Protects Cardiomyocytes from Anoxia/Reoxygenation Injury by 14-3-3η
por: Zhu, Meifang, et al.
Publicado: (2018)

Protective effect of gastrodin on myocardial ischemia-reperfusion injury and the expression of Bax and Bcl-2
por: Han, Xiao, et al.
Publicado: (2019)

A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain
por: Han, Wen-Juan, et al.
Publicado: (2015)

Gastrodin and Vascular Dementia: Advances and Current Perspectives
por: Deng, Chujun, et al.
Publicado: (2022)

Effectiveness of gastrodin for migraine: A meta-analysis
por: Zhou, Xiu, et al.
Publicado: (2022)

Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
por: Wang, Yuhong, et al.
Publicado: (2022)

A single low-energy shockwave pulse opens blood-cerebrospinal fluid barriers and facilitates gastrodin delivery to alleviate epilepsy
por: Kung, Yi, et al.
Publicado: (2021)

Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally-induced diabetes mellitus
por: Qi, Yu-Han, et al.
Publicado: (2019)

Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro
por: Medelin, M., et al.
Publicado: (2018)

Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation
por: Mu, Zhi-Hao, et al.
Publicado: (2023)

Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
por: Yan, Jinyuan, et al.
Publicado: (2019)

Gastrodin improves preeclampsia‐induced cell apoptosis by regulation of TLR4/NF‐κB in rats
por: Mei, Zhixiong, et al.
Publicado: (2020)

A Review on Central Nervous System Effects of Gastrodin
por: Liu, Yuan, et al.
Publicado: (2018)

Role of Intestinal Microbiota in Metabolism of Gastrodin In Vitro and In Vivo
por: Nepal, Mahesh Raj, et al.
Publicado: (2019)

Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration
por: Li, Yi, et al.
Publicado: (2022)

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses
por: Lu, Jianning, et al.
Publicado: (2015)

Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p
por: Song, Jin-Jin, et al.
Publicado: (2022)

Moxibustion Eases Chronic Inflammatory Visceral Pain In Rats Via MAPK Signaling Pathway In The Spinal Cord
por: Huang, Yan, et al.
Publicado: (2019)

Gastrodin Ameliorates Motor Learning Deficits Through Preserving Cerebellar Long-Term Depression Pathways in Diabetic Rats
por: Deng, Cheng-Kun, et al.
Publicado: (2019)

Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway
por: Zhang, Zhuo, et al.
Publicado: (2017)

Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid★
por: Sun, Guifang, et al.
Publicado: (2012)

Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression
por: Li, Gang, et al.
Publicado: (2018)

Gastrodin relieves inflammation injury induced by lipopolysaccharides in MRC‐5 cells by up‐regulation of miR‐103
por: Xi, Zhuona, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ru8vgj42huaj5bs8a6pmsvdm7r