The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis

An impairment of cardiac function is a key feature of the cardiovascular failure associated with sepsis. Although there is some evidence that suppression of sarcoplasmic reticulum Ca(2+)-ATP-ase (SERCA2) contributes to septic cardiomyopathy, it is not known whether prevention of the down-regulation...

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Autores principales: Martin, Lukas, Horst, Klemens, Chiazza, Fausto, Oggero, Silvia, Collino, Massimo, Brandenburg, Klaus, Hildebrand, Frank, Marx, Gernot, Thiemermann, Christoph, Schuerholz, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112529/
https://www.ncbi.nlm.nih.gov/pubmed/27853260
http://dx.doi.org/10.1038/srep37277

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