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Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study
As a significant type of cerebral cortical convolution pattern, the gyrus is widely preserved across species. Although many hypotheses have been proposed to study the underlying mechanisms of gyrus formation, it is currently still far from clear which factors contribute to the regulation of consiste...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112531/ https://www.ncbi.nlm.nih.gov/pubmed/27853245 http://dx.doi.org/10.1038/srep37272 |
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author | Zhang, Tuo Razavi, Mir Jalil Li, Xiao Chen, Hanbo Liu, Tianming Wang, Xianqiao |
author_facet | Zhang, Tuo Razavi, Mir Jalil Li, Xiao Chen, Hanbo Liu, Tianming Wang, Xianqiao |
author_sort | Zhang, Tuo |
collection | PubMed |
description | As a significant type of cerebral cortical convolution pattern, the gyrus is widely preserved across species. Although many hypotheses have been proposed to study the underlying mechanisms of gyrus formation, it is currently still far from clear which factors contribute to the regulation of consistent gyrus formation. In this paper, we employ a joint analysis scheme of experimental data and computational modeling to investigate the fundamental mechanism of gyrus formation. Experimental data on mature human brains and fetal brains show that thicker cortices are consistently found in gyral regions and gyral cortices have higher growth rates. We hypothesize that gyral convolution patterns might stem from heterogeneous regional growth in the cortex. Our computational simulations show that gyral convex patterns may occur in locations where the cortical plate grows faster than the cortex of the brain. Global differential growth can only produce a random gyrification pattern, but it cannot guarantee gyrus formation at certain locations. Based on extensive computational modeling and simulations, it is suggested that a special area in the cerebral cortex with a relatively faster growth speed could consistently engender gyri. |
format | Online Article Text |
id | pubmed-5112531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51125312016-11-23 Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study Zhang, Tuo Razavi, Mir Jalil Li, Xiao Chen, Hanbo Liu, Tianming Wang, Xianqiao Sci Rep Article As a significant type of cerebral cortical convolution pattern, the gyrus is widely preserved across species. Although many hypotheses have been proposed to study the underlying mechanisms of gyrus formation, it is currently still far from clear which factors contribute to the regulation of consistent gyrus formation. In this paper, we employ a joint analysis scheme of experimental data and computational modeling to investigate the fundamental mechanism of gyrus formation. Experimental data on mature human brains and fetal brains show that thicker cortices are consistently found in gyral regions and gyral cortices have higher growth rates. We hypothesize that gyral convolution patterns might stem from heterogeneous regional growth in the cortex. Our computational simulations show that gyral convex patterns may occur in locations where the cortical plate grows faster than the cortex of the brain. Global differential growth can only produce a random gyrification pattern, but it cannot guarantee gyrus formation at certain locations. Based on extensive computational modeling and simulations, it is suggested that a special area in the cerebral cortex with a relatively faster growth speed could consistently engender gyri. Nature Publishing Group 2016-11-17 /pmc/articles/PMC5112531/ /pubmed/27853245 http://dx.doi.org/10.1038/srep37272 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhang, Tuo Razavi, Mir Jalil Li, Xiao Chen, Hanbo Liu, Tianming Wang, Xianqiao Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study |
title | Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study |
title_full | Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study |
title_fullStr | Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study |
title_full_unstemmed | Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study |
title_short | Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study |
title_sort | mechanism of consistent gyrus formation: an experimental and computational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112531/ https://www.ncbi.nlm.nih.gov/pubmed/27853245 http://dx.doi.org/10.1038/srep37272 |
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