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Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
The aspartyl protease β-site APP cleaving enzyme, BACE1, is the rate-limiting enzyme involved in the production of amyloid-β peptide, which accumulates in both sporadic and familial cases of Alzheimer’s disease and is at the center of gravity of the amyloid cascade hypothesis. In this context, unrav...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112606/ https://www.ncbi.nlm.nih.gov/pubmed/27853315 http://dx.doi.org/10.1038/srep37436 |