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Myofibroblast distribution is associated with invasive growth types of colorectal cancer

Both the invasive growth types of colorectal cancer (CRC) and the number of myofibroblasts have been associated with histopathological factors such as lymph node and liver metastasis, and local recurrence. However, there are few studies, that have assessed the association between invasive growth typ...

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Autores principales: Takatsuna, Masafumi, Morohashi, Satoko, Yoshizawa, Tadashi, Hirai, Hideaki, Haga, Toshihiro, Ota, Rie, Saito, Kensuke, Wu, Yunyan, Seino, Hiroko, Aoyagi, Yutaka, Terai, Shuji, Kijima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112613/
https://www.ncbi.nlm.nih.gov/pubmed/27779697
http://dx.doi.org/10.3892/or.2016.5202
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author Takatsuna, Masafumi
Morohashi, Satoko
Yoshizawa, Tadashi
Hirai, Hideaki
Haga, Toshihiro
Ota, Rie
Saito, Kensuke
Wu, Yunyan
Seino, Hiroko
Aoyagi, Yutaka
Terai, Shuji
Kijima, Hiroshi
author_facet Takatsuna, Masafumi
Morohashi, Satoko
Yoshizawa, Tadashi
Hirai, Hideaki
Haga, Toshihiro
Ota, Rie
Saito, Kensuke
Wu, Yunyan
Seino, Hiroko
Aoyagi, Yutaka
Terai, Shuji
Kijima, Hiroshi
author_sort Takatsuna, Masafumi
collection PubMed
description Both the invasive growth types of colorectal cancer (CRC) and the number of myofibroblasts have been associated with histopathological factors such as lymph node and liver metastasis, and local recurrence. However, there are few studies, that have assessed the association between invasive growth type and myofibroblast distribution in CRC. We aimed to evaluate the relationship between the clinicopathological factors of CRC and two invasive growth types, the expanding and infiltrating types. We categorized 150 cases of pT3 CRC into the expanding and infiltrating types and measured the myofibroblast density of three histological layers: the submucosa (SM), the muscularis propria (MP) and the subserosa (SS). We compared these two invasive growth types and analyzed the relationship between clinicopathological factors and myofibroblast density. Myofibroblast density was significantly higher in the infiltrating type than that in the expanding type (P<0.05). In the lymph node metastasis-positive group of the infiltrating type, myofibroblast density in MP was significantly higher than that in the lymph node metastasis-negative group (P<0.001). In the infiltrating type, the group with the higher level of lymphatic invasion had a significantly higher density of myofibroblasts in the MP than the group with the lower level of lymphatic invasion (P<0.01). These results suggest that myofibroblasts participate more in the infiltrating type compared with the expanding type of CRC. It would appear that myofibroblasts present in the MP play an important role in the malignant potential of the infiltrating type compared to the expanding type.
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spelling pubmed-51126132016-11-28 Myofibroblast distribution is associated with invasive growth types of colorectal cancer Takatsuna, Masafumi Morohashi, Satoko Yoshizawa, Tadashi Hirai, Hideaki Haga, Toshihiro Ota, Rie Saito, Kensuke Wu, Yunyan Seino, Hiroko Aoyagi, Yutaka Terai, Shuji Kijima, Hiroshi Oncol Rep Articles Both the invasive growth types of colorectal cancer (CRC) and the number of myofibroblasts have been associated with histopathological factors such as lymph node and liver metastasis, and local recurrence. However, there are few studies, that have assessed the association between invasive growth type and myofibroblast distribution in CRC. We aimed to evaluate the relationship between the clinicopathological factors of CRC and two invasive growth types, the expanding and infiltrating types. We categorized 150 cases of pT3 CRC into the expanding and infiltrating types and measured the myofibroblast density of three histological layers: the submucosa (SM), the muscularis propria (MP) and the subserosa (SS). We compared these two invasive growth types and analyzed the relationship between clinicopathological factors and myofibroblast density. Myofibroblast density was significantly higher in the infiltrating type than that in the expanding type (P<0.05). In the lymph node metastasis-positive group of the infiltrating type, myofibroblast density in MP was significantly higher than that in the lymph node metastasis-negative group (P<0.001). In the infiltrating type, the group with the higher level of lymphatic invasion had a significantly higher density of myofibroblasts in the MP than the group with the lower level of lymphatic invasion (P<0.01). These results suggest that myofibroblasts participate more in the infiltrating type compared with the expanding type of CRC. It would appear that myofibroblasts present in the MP play an important role in the malignant potential of the infiltrating type compared to the expanding type. D.A. Spandidos 2016-12 2016-10-25 /pmc/articles/PMC5112613/ /pubmed/27779697 http://dx.doi.org/10.3892/or.2016.5202 Text en Copyright: © Takatsuna et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Takatsuna, Masafumi
Morohashi, Satoko
Yoshizawa, Tadashi
Hirai, Hideaki
Haga, Toshihiro
Ota, Rie
Saito, Kensuke
Wu, Yunyan
Seino, Hiroko
Aoyagi, Yutaka
Terai, Shuji
Kijima, Hiroshi
Myofibroblast distribution is associated with invasive growth types of colorectal cancer
title Myofibroblast distribution is associated with invasive growth types of colorectal cancer
title_full Myofibroblast distribution is associated with invasive growth types of colorectal cancer
title_fullStr Myofibroblast distribution is associated with invasive growth types of colorectal cancer
title_full_unstemmed Myofibroblast distribution is associated with invasive growth types of colorectal cancer
title_short Myofibroblast distribution is associated with invasive growth types of colorectal cancer
title_sort myofibroblast distribution is associated with invasive growth types of colorectal cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112613/
https://www.ncbi.nlm.nih.gov/pubmed/27779697
http://dx.doi.org/10.3892/or.2016.5202
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