Cargando…
Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study
BACKGROUND: Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population. METHODS: We conducted a retrospective cohort st...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112692/ https://www.ncbi.nlm.nih.gov/pubmed/27852248 http://dx.doi.org/10.1186/s12890-016-0312-3 |
_version_ | 1782468053400813568 |
---|---|
author | Shen, Te-Chun Chen, Hsuan-Ju Wei, Chang-Ching Chen, Chia-Hung Tu, Chih-Yen Hsia, Te-Chun Shih, Chuen-Ming Hsu, Wu-Huei Sung, Fung-Chang Bau, Da-Tian |
author_facet | Shen, Te-Chun Chen, Hsuan-Ju Wei, Chang-Ching Chen, Chia-Hung Tu, Chih-Yen Hsia, Te-Chun Shih, Chuen-Ming Hsu, Wu-Huei Sung, Fung-Chang Bau, Da-Tian |
author_sort | Shen, Te-Chun |
collection | PubMed |
description | BACKGROUND: Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population. METHODS: We conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS group included 4725 adult patients diagnosed between 2000 and 2006. Each patient was frequency-matched with four people without SS by sex, age and year of diagnosis. The occurrence and hazard ratio (HR) of asthma was monitored by the end of 2011. RESULTS: The overall incidence density of asthma was 1.62-fold higher in the primary SS group than in the non-SS group (9.86 vs. 6.10 per 1000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.38 [95% confidence interval (CI) = 1.21–1.58]. Stratified analyses by sex, age group, and presence of comorbidity revealed that asthma incidences were all higher in the primary SS group than in the non-SS group, and the relative HRs of asthma associated with primary SS were significant in all subgroups. CONCLUSION: Patients with primary SS are associated with an increased risk of developing asthma. We should pay more attention to this group of individuals and provide them with appropriate support. |
format | Online Article Text |
id | pubmed-5112692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51126922016-11-25 Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study Shen, Te-Chun Chen, Hsuan-Ju Wei, Chang-Ching Chen, Chia-Hung Tu, Chih-Yen Hsia, Te-Chun Shih, Chuen-Ming Hsu, Wu-Huei Sung, Fung-Chang Bau, Da-Tian BMC Pulm Med Research Article BACKGROUND: Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population. METHODS: We conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS group included 4725 adult patients diagnosed between 2000 and 2006. Each patient was frequency-matched with four people without SS by sex, age and year of diagnosis. The occurrence and hazard ratio (HR) of asthma was monitored by the end of 2011. RESULTS: The overall incidence density of asthma was 1.62-fold higher in the primary SS group than in the non-SS group (9.86 vs. 6.10 per 1000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.38 [95% confidence interval (CI) = 1.21–1.58]. Stratified analyses by sex, age group, and presence of comorbidity revealed that asthma incidences were all higher in the primary SS group than in the non-SS group, and the relative HRs of asthma associated with primary SS were significant in all subgroups. CONCLUSION: Patients with primary SS are associated with an increased risk of developing asthma. We should pay more attention to this group of individuals and provide them with appropriate support. BioMed Central 2016-11-16 /pmc/articles/PMC5112692/ /pubmed/27852248 http://dx.doi.org/10.1186/s12890-016-0312-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Shen, Te-Chun Chen, Hsuan-Ju Wei, Chang-Ching Chen, Chia-Hung Tu, Chih-Yen Hsia, Te-Chun Shih, Chuen-Ming Hsu, Wu-Huei Sung, Fung-Chang Bau, Da-Tian Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study |
title | Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study |
title_full | Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study |
title_fullStr | Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study |
title_full_unstemmed | Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study |
title_short | Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study |
title_sort | risk of asthma in patients with primary sjögren’s syndrome: a retrospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112692/ https://www.ncbi.nlm.nih.gov/pubmed/27852248 http://dx.doi.org/10.1186/s12890-016-0312-3 |
work_keys_str_mv | AT shentechun riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT chenhsuanju riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT weichangching riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT chenchiahung riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT tuchihyen riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT hsiatechun riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT shihchuenming riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT hsuwuhuei riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT sungfungchang riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy AT baudatian riskofasthmainpatientswithprimarysjogrenssyndromearetrospectivecohortstudy |