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A case series of atypical presentation of Zika Virus infection in Singapore

BACKGROUND: The World Health Organization’s and Centers for Disease Control and Prevention’s definition of Zika infection are symptoms of fever, rash, joint pain, myalgia, headache and conjunctivitis. The diagnosis of Zika infection is based on the clinical history, physical examination and laborato...

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Autores principales: Xu, Bang Yu, Low, Sher Guan, Tan, Richard Tiong Heng, Vasanwala, Farhad Fakhrudin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112881/
https://www.ncbi.nlm.nih.gov/pubmed/27855636
http://dx.doi.org/10.1186/s12879-016-2032-y
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author Xu, Bang Yu
Low, Sher Guan
Tan, Richard Tiong Heng
Vasanwala, Farhad Fakhrudin
author_facet Xu, Bang Yu
Low, Sher Guan
Tan, Richard Tiong Heng
Vasanwala, Farhad Fakhrudin
author_sort Xu, Bang Yu
collection PubMed
description BACKGROUND: The World Health Organization’s and Centers for Disease Control and Prevention’s definition of Zika infection are symptoms of fever, rash, joint pain, myalgia, headache and conjunctivitis. The diagnosis of Zika infection is based on the clinical history, physical examination and laboratory investigations which includes blood and urine Zika virus Polymerase Chain Reaction. CASE PRESENTATION: Two patients presented with atypical presentation of Zika infection to Sengkang Health, Alexandra Hospital during the recent Zika outbreak in Singapore in August 2016. Madam A presented with isolated generalized rash with no fever, joint pain, myalgia, headache or conjunctivitis. Mr. B presented with isolated fever of 39.4 °C with no rash, joint pain, myalgia, headache or conjunctivitis. Both patients’ blood Zika Polymerase Chain Reactions were positive at the time of presentation. CONCLUSION: The described case reports illustrated the challenges that our community Family Physicians faced in diagnosing patients infected with Zika virus. Coupled with the knowledge that most patients are asymptomatic, Family Physicians need to have a high index of clinical suspicion for early identification of patients infected with Zika virus, so as to institute timely treatment and appropriate measures to mitigate the outbreak of Zika infection in the community. Appropriate epidemiological measures such as ensuring prompt and thorough contact tracing of the cases are instrumental in the control of this public health problem.
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spelling pubmed-51128812016-11-25 A case series of atypical presentation of Zika Virus infection in Singapore Xu, Bang Yu Low, Sher Guan Tan, Richard Tiong Heng Vasanwala, Farhad Fakhrudin BMC Infect Dis Case Report BACKGROUND: The World Health Organization’s and Centers for Disease Control and Prevention’s definition of Zika infection are symptoms of fever, rash, joint pain, myalgia, headache and conjunctivitis. The diagnosis of Zika infection is based on the clinical history, physical examination and laboratory investigations which includes blood and urine Zika virus Polymerase Chain Reaction. CASE PRESENTATION: Two patients presented with atypical presentation of Zika infection to Sengkang Health, Alexandra Hospital during the recent Zika outbreak in Singapore in August 2016. Madam A presented with isolated generalized rash with no fever, joint pain, myalgia, headache or conjunctivitis. Mr. B presented with isolated fever of 39.4 °C with no rash, joint pain, myalgia, headache or conjunctivitis. Both patients’ blood Zika Polymerase Chain Reactions were positive at the time of presentation. CONCLUSION: The described case reports illustrated the challenges that our community Family Physicians faced in diagnosing patients infected with Zika virus. Coupled with the knowledge that most patients are asymptomatic, Family Physicians need to have a high index of clinical suspicion for early identification of patients infected with Zika virus, so as to institute timely treatment and appropriate measures to mitigate the outbreak of Zika infection in the community. Appropriate epidemiological measures such as ensuring prompt and thorough contact tracing of the cases are instrumental in the control of this public health problem. BioMed Central 2016-11-17 /pmc/articles/PMC5112881/ /pubmed/27855636 http://dx.doi.org/10.1186/s12879-016-2032-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Xu, Bang Yu
Low, Sher Guan
Tan, Richard Tiong Heng
Vasanwala, Farhad Fakhrudin
A case series of atypical presentation of Zika Virus infection in Singapore
title A case series of atypical presentation of Zika Virus infection in Singapore
title_full A case series of atypical presentation of Zika Virus infection in Singapore
title_fullStr A case series of atypical presentation of Zika Virus infection in Singapore
title_full_unstemmed A case series of atypical presentation of Zika Virus infection in Singapore
title_short A case series of atypical presentation of Zika Virus infection in Singapore
title_sort case series of atypical presentation of zika virus infection in singapore
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112881/
https://www.ncbi.nlm.nih.gov/pubmed/27855636
http://dx.doi.org/10.1186/s12879-016-2032-y
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