Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets

Previous studies in Chinese hamster ovary cells showed that truncational mutations of β3 at sites of F(754) and Y(759) mimicking calpain cleavage regulate integrin signaling. The roles of the sequence from F(754) to C-terminus and the conservative N(756)ITY(759) motif in platelet function have yet t...

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Detalles Bibliográficos
Autores principales: Shi, Xiaofeng, Yang, Jichun, Cui, Xiongying, Huang, Jiansong, Long, Zhangbiao, Zhou, Yulan, Liu, Ping, Tao, Lanlan, Ruan, Zheng, Xiao, Bing, Zhang, Wei, Li, Dongya, Dai, Kesheng, Mao, Jianhua, Xi, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112943/
https://www.ncbi.nlm.nih.gov/pubmed/27851790
http://dx.doi.org/10.1371/journal.pone.0166136

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