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Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study

BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus. Previous studies about risk factors for SFTSV infection have yielded inconsistent results, and behavior factors have not been fully clarified. METHODS: A community-based, 1:...

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Autores principales: Hu, Jian-li, Li, Zhi-feng, Wang, Xiao-chen, Hong, Lei, He, Hao, Chen, Wei-guo, Li, Lu-xun, Shen, Ai-hua, Liu, Xue-jian, Yuan, Shou-guo, Zhou, Jian-gang, Tan, Wen-wen, Zhou, Wei-zhong, Tang, Fen-yang, Zhu, Feng-cai, Bao, Chang-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112944/
https://www.ncbi.nlm.nih.gov/pubmed/27846273
http://dx.doi.org/10.1371/journal.pone.0166611
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author Hu, Jian-li
Li, Zhi-feng
Wang, Xiao-chen
Hong, Lei
He, Hao
Chen, Wei-guo
Li, Lu-xun
Shen, Ai-hua
Liu, Xue-jian
Yuan, Shou-guo
Zhou, Jian-gang
Tan, Wen-wen
Zhou, Wei-zhong
Tang, Fen-yang
Zhu, Feng-cai
Bao, Chang-jun
author_facet Hu, Jian-li
Li, Zhi-feng
Wang, Xiao-chen
Hong, Lei
He, Hao
Chen, Wei-guo
Li, Lu-xun
Shen, Ai-hua
Liu, Xue-jian
Yuan, Shou-guo
Zhou, Jian-gang
Tan, Wen-wen
Zhou, Wei-zhong
Tang, Fen-yang
Zhu, Feng-cai
Bao, Chang-jun
author_sort Hu, Jian-li
collection PubMed
description BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus. Previous studies about risk factors for SFTSV infection have yielded inconsistent results, and behavior factors have not been fully clarified. METHODS: A community-based, 1:4 matched case-control study was carried out to investigate the risk factors for SFTS in China. Cases of SFTS were defined as laboratory-confirmed cases that tested positive for real-time PCR (RT-PCR) for severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) or positive for IgM antibodies against SFTSV. Controls of four neighborhood subjects were selected by matching for sex, age, and occupation. Standardized questionnaires were used to collect detailed information about their demographics and risk factors for SFTSV infection. RESULTS: A total of 334 subjects participated in the study including 69 cases and 265 controls. The median age of the cases was 59.5 years, 55.1% were male, and 87.0% were farmers. No differences in demographics were observed between cases and controls. In the final multivariate analysis, tick bites two weeks prior to disease onset (OR = 8.04, 95%CI 3.34–19.37) and the presence of weeds and shrubs around the house (OR = 3.46, 95%CI 0.96–12.46) were found to be risk factors for SFTSV infection; taking preventative measures during outdoor activities (OR = 0.12, 95%CI 0.01–1.01) provided greater protection from SFTSV infection. CONCLUSIONS: Our results further confirm that SFTSV is transmitted by tick bites and prove that preventative measures that reduce exposure to ticks can prevent SFTSV infection. More efforts should be directed toward health education and behavior change for high-risk populations, especially outdoor workers, in SFTS endemic areas.
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spelling pubmed-51129442016-12-08 Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study Hu, Jian-li Li, Zhi-feng Wang, Xiao-chen Hong, Lei He, Hao Chen, Wei-guo Li, Lu-xun Shen, Ai-hua Liu, Xue-jian Yuan, Shou-guo Zhou, Jian-gang Tan, Wen-wen Zhou, Wei-zhong Tang, Fen-yang Zhu, Feng-cai Bao, Chang-jun PLoS One Research Article BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus. Previous studies about risk factors for SFTSV infection have yielded inconsistent results, and behavior factors have not been fully clarified. METHODS: A community-based, 1:4 matched case-control study was carried out to investigate the risk factors for SFTS in China. Cases of SFTS were defined as laboratory-confirmed cases that tested positive for real-time PCR (RT-PCR) for severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) or positive for IgM antibodies against SFTSV. Controls of four neighborhood subjects were selected by matching for sex, age, and occupation. Standardized questionnaires were used to collect detailed information about their demographics and risk factors for SFTSV infection. RESULTS: A total of 334 subjects participated in the study including 69 cases and 265 controls. The median age of the cases was 59.5 years, 55.1% were male, and 87.0% were farmers. No differences in demographics were observed between cases and controls. In the final multivariate analysis, tick bites two weeks prior to disease onset (OR = 8.04, 95%CI 3.34–19.37) and the presence of weeds and shrubs around the house (OR = 3.46, 95%CI 0.96–12.46) were found to be risk factors for SFTSV infection; taking preventative measures during outdoor activities (OR = 0.12, 95%CI 0.01–1.01) provided greater protection from SFTSV infection. CONCLUSIONS: Our results further confirm that SFTSV is transmitted by tick bites and prove that preventative measures that reduce exposure to ticks can prevent SFTSV infection. More efforts should be directed toward health education and behavior change for high-risk populations, especially outdoor workers, in SFTS endemic areas. Public Library of Science 2016-11-15 /pmc/articles/PMC5112944/ /pubmed/27846273 http://dx.doi.org/10.1371/journal.pone.0166611 Text en © 2016 Hu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hu, Jian-li
Li, Zhi-feng
Wang, Xiao-chen
Hong, Lei
He, Hao
Chen, Wei-guo
Li, Lu-xun
Shen, Ai-hua
Liu, Xue-jian
Yuan, Shou-guo
Zhou, Jian-gang
Tan, Wen-wen
Zhou, Wei-zhong
Tang, Fen-yang
Zhu, Feng-cai
Bao, Chang-jun
Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study
title Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study
title_full Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study
title_fullStr Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study
title_full_unstemmed Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study
title_short Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study
title_sort risk factors for bunyavirus-associated severe fever with thrombocytopenia syndrome: a community-based case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112944/
https://www.ncbi.nlm.nih.gov/pubmed/27846273
http://dx.doi.org/10.1371/journal.pone.0166611
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