The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53

As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3) remain elusive, which limits our understanding of its normal cellular function and that of pathogenic mechanism of spinocerebellar ataxia type 3 (SCA3). Here, we identify p53 to be a novel substrate of ATX-3. ATX-3...

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Detalles Bibliográficos
Autores principales: Liu, Hongmei, Li, Xiaoling, Ning, Guozhu, Zhu, Shu, Ma, Xiaolu, Liu, Xiuli, Liu, Chunying, Huang, Min, Schmitt, Ina, Wüllner, Ullrich, Niu, Yamei, Guo, Caixia, Wang, Qiang, Tang, Tie-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112960/
https://www.ncbi.nlm.nih.gov/pubmed/27851749
http://dx.doi.org/10.1371/journal.pbio.2000733

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