Stereochemical Control of Enzymatic Carbon–Carbon Bond‐Forming Michael‐Type Additions by “Substrate Engineering”

The enzyme 4‐oxalocrotonate tautomerase (4‐OT) promiscuously catalyzes the Michael‐type addition of acetaldehyde to β‐nitrostyrene derivatives to yield chiral γ‐nitroaldehydes, which are important precursors for pharmaceutically active γ‐aminobutyric acids. In this study, we investigated the effect...

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Detalles Bibliográficos
Autores principales: Miao, Yufeng, Tepper, Pieter G., Geertsema, Edzard M., Poelarends, Gerrit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113669/
https://www.ncbi.nlm.nih.gov/pubmed/27917069
http://dx.doi.org/10.1002/ejoc.201601126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113669/
https://www.ncbi.nlm.nih.gov/pubmed/27917069
http://dx.doi.org/10.1002/ejoc.201601126

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