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The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference

BACKGROUND: The Patient‐Oriented Eczema Measure (POEM) has been recommended as the core patient‐reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine...

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Autores principales: Gaunt, D. M., Metcalfe, C., Ridd, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113674/
https://www.ncbi.nlm.nih.gov/pubmed/27232584
http://dx.doi.org/10.1111/all.12942
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author Gaunt, D. M.
Metcalfe, C.
Ridd, M.
author_facet Gaunt, D. M.
Metcalfe, C.
Ridd, M.
author_sort Gaunt, D. M.
collection PubMed
description BACKGROUND: The Patient‐Oriented Eczema Measure (POEM) has been recommended as the core patient‐reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema. METHODS: Responsiveness to change by repeated administrations of the POEM was investigated in relation to change recalled using the Parent Global Assessment (PGA) measure. Five methods of determining the MCID of the POEM were employed; three anchor‐based methods using PGA as the anchor: the within‐patient score change, between‐patient score change and sensitivity and specificity method, and two distribution‐based methods: effect size estimate and the one half standard deviation of the baseline distribution of POEM scores. RESULTS: Successive POEM scores were found to be responsive to change in eczema severity. The MCID of the POEM change score, in relation to a slight improvement in eczema severity as recalled by parents on the PGA, estimated by the within‐patient score change (4.27), the between‐patient score change (2.89) and the sensitivity and specificity method (3.00) was similar to the one half standard deviation of the POEM baseline scores (2.94) and the effect size estimate (2.50). CONCLUSIONS: The Patient‐Oriented Eczema Measure as applied to young children is responsive to change, and the MCID is around 3. This study will encourage the use of POEM and aid in determining sample size for future randomized controlled trials of treatments for eczema in young children.
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spelling pubmed-51136742016-12-02 The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference Gaunt, D. M. Metcalfe, C. Ridd, M. Allergy ORIGINAL ARTICLES BACKGROUND: The Patient‐Oriented Eczema Measure (POEM) has been recommended as the core patient‐reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema. METHODS: Responsiveness to change by repeated administrations of the POEM was investigated in relation to change recalled using the Parent Global Assessment (PGA) measure. Five methods of determining the MCID of the POEM were employed; three anchor‐based methods using PGA as the anchor: the within‐patient score change, between‐patient score change and sensitivity and specificity method, and two distribution‐based methods: effect size estimate and the one half standard deviation of the baseline distribution of POEM scores. RESULTS: Successive POEM scores were found to be responsive to change in eczema severity. The MCID of the POEM change score, in relation to a slight improvement in eczema severity as recalled by parents on the PGA, estimated by the within‐patient score change (4.27), the between‐patient score change (2.89) and the sensitivity and specificity method (3.00) was similar to the one half standard deviation of the POEM baseline scores (2.94) and the effect size estimate (2.50). CONCLUSIONS: The Patient‐Oriented Eczema Measure as applied to young children is responsive to change, and the MCID is around 3. This study will encourage the use of POEM and aid in determining sample size for future randomized controlled trials of treatments for eczema in young children. John Wiley and Sons Inc. 2016-07-13 2016-11 /pmc/articles/PMC5113674/ /pubmed/27232584 http://dx.doi.org/10.1111/all.12942 Text en © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle ORIGINAL ARTICLES
Gaunt, D. M.
Metcalfe, C.
Ridd, M.
The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
title The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
title_full The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
title_fullStr The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
title_full_unstemmed The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
title_short The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
title_sort patient‐oriented eczema measure in young children: responsiveness and minimal clinically important difference
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113674/
https://www.ncbi.nlm.nih.gov/pubmed/27232584
http://dx.doi.org/10.1111/all.12942
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