Cargando…

Intermedin(1–53) Protects Against Myocardial Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Inflammation Induced by Homocysteine in Apolipoprotein E-Deficient Mice

Aim: Endoplasmic reticulum stress (ERS) and inflammation participate in cardiac fibrosis. Importantly, a novel paracrine/autocrine peptide intermedin(1–53) (IMD(1–53)) in the heart inhibits myocardial fibrosis in rats. However, the mechanisms are yet to be fully elucidated. Methods: Myocardial fibro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jin-Sheng, Hou, Yue-Long, Lu, Wei-Wei, Ni, Xian-Qiang, Lin, Fan, Yu, Yan-Rong, Tang, Chao-Shu, Qi, Yong-Fen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japan Atherosclerosis Society 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113747/ https://www.ncbi.nlm.nih.gov/pubmed/27052784 http://dx.doi.org/10.5551/jat.34082

Ejemplares similares

Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress
por: Wang, Yanhong, et al.
Publicado: (2015)

Intermedin 1-53 Inhibits Myocardial Fibrosis in Rats by Down-Regulating Transforming Growth Factor-β
por: Fang, Jian, et al.
Publicado: (2017)

Intermedin protects thapsigargin-induced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca(2+)-ATPase
por: Li, Zhidong, et al.
Publicado: (2021)

Intermedin(1-53) attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages
por: Ren, Jin-Ling, et al.
Publicado: (2021)

Intermedin(1-53) attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1
por: Chen, Yao, et al.
Publicado: (2020)

Inhibition of Endoplasmic Reticulum Stress and Atherosclerosis by 2-Aminopurine in Apolipoprotein E-Deficient Mice
por: Zhou, Lichun, et al.
Publicado: (2013)

Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis
por: Wu, Xun, et al.
Publicado: (2018)

Homocysteine Inhibits Hepatocyte Proliferation via Endoplasmic Reticulum Stress
por: Yu, Xue, et al.
Publicado: (2013)

Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress
por: Preninka, Arini Isnani, et al.
Publicado: (2022)

Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration
por: Feng, Juan, et al.
Publicado: (2016)

Effects of homocysteine-induced endoplasmic reticulum protein on endoplasmic reticulum stress, autophagy, and neuronal apoptosis following intracerebral hemorrhage
por: Wu, Hui, et al.
Publicado: (2020)

Intermedin(1–53) enhances angiogenesis and attenuates adverse remodeling following myocardial infarction by activating AMP-activated protein kinase
por: Chen, Kankai, et al.
Publicado: (2017)

Cotranslocational insertion of apolipoprotein B into the inner leaflet of the endoplasmic reticulum
por: Pease, Richard J., et al.
Publicado: (1991)

Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats
por: Li, Hong, et al.
Publicado: (2013)

Homocysteine induces human mesangial cell apoptosis via the involvement of autophagy and endoplasmic reticulum stress
por: Liang, Shanshan, et al.
Publicado: (2019)

Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes
por: Guo, Qing, et al.
Publicado: (2017)

Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway
por: Ni, Xian-Qiang, et al.
Publicado: (2021)

Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress
por: Zhang, Zhimin, et al.
Publicado: (2017)

Multi-biological functions of intermedin in diseases
por: Yang, Zhi, et al.
Publicado: (2023)

Intermedin Attenuates LPS-induced Inflammation in the Rat Testis
por: Li, Lei, et al.
Publicado: (2013)

Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder
por: Zhang, Shan, et al.
Publicado: (2023)

Abnormal Mitochondria-Endoplasmic Reticulum Communication Promotes Myocardial Infarction
por: Cheng, Degang, et al.
Publicado: (2021)

Protective effect of intermedin on myocardial cell in a rat model of severe acute pancreatitis
por: Du, Xiaodong, et al.
Publicado: (2011)

The Modulation of Endoplasmic Reticulum Stress by Chemical Chaperone Upregulates Immune Negative Cytokine IL-35 in Apolipoprotein E-Deficient Mice
por: Wang, Bo, et al.
Publicado: (2014)

Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice
por: Kim, Hyun Ju, et al.
Publicado: (2023)

Sequential changes of endoplasmic reticulum stress and apoptosis in myocardial fibrosis of diabetes mellitus-induced rats
por: YANG, QIONG, et al.
Publicado: (2016)

The Prognostic Value of Intermedin in Patients with Breast Cancer
por: Lu, Yi-Min, et al.
Publicado: (2015)

Combined Hepatotoxicity and Toxicity Mechanism of Intermedine and Lycopsamine
por: Wang, Ziqi, et al.
Publicado: (2022)

Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction
por: Qiao, Xi, et al.
Publicado: (2017)

Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress
por: Liu, Shi-Meng, et al.
Publicado: (2022)

Alterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 Mutants
por: Giorgi, Carlotta, et al.
Publicado: (2016)

Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells
por: Zhang, Ting, et al.
Publicado: (2016)

Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress
por: Liu, Yuqing, et al.
Publicado: (2018)

Identification of Two Regions in Apolipoprotein B100 that are Exposed on the Cytosolic Side of the Endoplasmic Reticulum Membrane
por: Du, Xiaobo, et al.
Publicado: (1998)

Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function
por: Zhong, Ning, et al.
Publicado: (2009)

Featured interactome of homocysteine-inducible endoplasmic reticulum protein uncovers novel binding partners in response to ER stress
por: Su, Rui, et al.
Publicado: (2023)

Intermedin 1-53 Ameliorates Atrial Fibrosis and Reduces Inducibility of Atrial Fibrillation via TGF-β1/pSmad3 and Nox4 Pathway in a Rat Model of Heart Failure
por: Ma, Shenzhou, et al.
Publicado: (2023)

Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats
por: Yuan, Ying, et al.
Publicado: (2012)

Intermedin Suppresses Pressure Overload Cardiac Hypertrophy through Activation of Autophagy
por: Chen, HuaLi, et al.
Publicado: (2013)

Protein disulfide isomerases contribute differentially to the endoplasmic reticulum–associated degradation of apolipoprotein B and other substrates
por: Grubb, Sarah, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8vp9jkjti78lfeed4nga551uu7