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Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial Chemistry
Fragment‐based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, fragment linking has rarely been reported. Dynamic combinatorial chemistry (DCC) has become a powerful hit‐identification strategy for biologi...
Autores principales: | Mondal, Milon, Radeva, Nedyalka, Fanlo‐Virgós, Hugo, Otto, Sijbren, Klebe, Gerhard, Hirsch, Anna K. H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113778/ https://www.ncbi.nlm.nih.gov/pubmed/27400756 http://dx.doi.org/10.1002/anie.201603074 |
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