Cargando…

PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival

Cancer is one of the leading causes of death in America, and there is an urgent need for new therapeutic approaches. The progesterone receptor membrane component 1 (PGRMC1) is a cytoch-rome b(5) related protein that binds heme and is associated with signaling, apoptotic suppression and autophagy. PG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hampton, Kaia K., Stewart, Rachel, Napier, Dana, Claudio, Pier Paolo, Craven, Rolf J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113835/ https://www.ncbi.nlm.nih.gov/pubmed/27867772 http://dx.doi.org/10.4236/alc.2015.43006

Ejemplares similares

PGRMC1: a new biomarker for the estrogen receptor in breast cancer
por: Craven, Rolf J
Publicado: (2008)

PGRMC Proteins Are Coming of Age: A Special Issue on the Role of PGRMC1 and PGRMC2 in Metabolism and Cancer Biology
por: Cahill, Michael A., et al.
Publicado: (2021)

PGRMC1 and PGRMC2 in uterine physiology and disease
por: Pru, James K., et al.
Publicado: (2013)

Progesterone Receptor Membrane Component (PGRMC)1 and PGRMC2 and Their Roles in Ovarian and Endometrial Cancer
por: Peluso, John J., et al.
Publicado: (2021)

Pathways driving the endocytosis of mutant and wild-type EGFR in cancer
por: Hampton, Kaia K., et al.
Publicado: (2014)

Insights on the Role of PGRMC1 in Mitotic and Meiotic Cell Division
por: Lodde, Valentina, et al.
Publicado: (2022)

Epitope mapping of anti-PGRMC1 antibodies reveals the non-conventional membrane topology of PGRMC1 on the cell surface
por: Kim, Ji Yea, et al.
Publicado: (2019)

Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish
por: Wu, Xin-Jun, et al.
Publicado: (2018)

Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling
por: Cao, Ting, et al.
Publicado: (2021)

PGRMC2 is an Intracellular Heme Chaperone Critical for Adipocyte Function
por: Galmozzi, Andrea, et al.
Publicado: (2019)

Comprehensive Analysis of the Implication of PGRMC1 in Triple-Negative Breast Cancer
por: Xu, Xin, et al.
Publicado: (2021)

The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide
por: Wang-Eckhardt, Lihua, et al.
Publicado: (2021)

Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers
por: Jühlen, Ramona, et al.
Publicado: (2018)

PGRMC1 regulation by phosphorylation: potential new insights in controlling biological activity!
por: Cahill, Michael A., et al.
Publicado: (2016)

Pgrmc1: new roles in the microglial mediation of progesterone-antagonism of estradiol-dependent neurite sprouting and in microglial activation
por: Bali, N., et al.
Publicado: (2013)

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
por: Xu, Jinbin, et al.
Publicado: (2011)

Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1
por: Kabe, Yasuaki, et al.
Publicado: (2018)

PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central Nervous System
por: Huang, Kun, et al.
Publicado: (2021)

PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
por: You, Ji Hyeon, et al.
Publicado: (2021)

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity
por: Izzo, Nicholas J., et al.
Publicado: (2014)

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth
por: Thejer, Bashar M., et al.
Publicado: (2020)

PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease
por: Thejer, Bashar M., et al.
Publicado: (2020)

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
por: Kabe, Yasuaki, et al.
Publicado: (2016)

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death
por: Zeng, Chenbo, et al.
Publicado: (2019)

Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1
por: Neubauer, Hans, et al.
Publicado: (2008)

Cloning, mapping and molecular characterization of porcine progesterone receptor membrane component 2 (PGRMC2) gene
por: Chen, Congying, et al.
Publicado: (2010)

Identification of the Sigma-2 Receptor: Distinct from the Progesterone Receptor Membrane Component 1 (PGRMC1)
por: Hiranita, Takato
Publicado: (2016)

Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities
por: Zhao, Yue, et al.
Publicado: (2020)

Loss of PGRMC1 Delays the Progression of Hepatocellular Carcinoma via Suppression of Pro-Inflammatory Immune Responses
por: Lee, Sang R., et al.
Publicado: (2021)

New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression
por: Kamińska, Joanna, et al.
Publicado: (2023)

Correction: Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1
por: Neubauer, Hans, et al.
Publicado: (2009)

Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression
por: Zhao, Guangfeng, et al.
Publicado: (2015)

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones
por: Chen, Yu-Jie, et al.
Publicado: (2021)

Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo
por: He, Ying, et al.
Publicado: (2022)

PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
por: Tsuru, Atsuya, et al.
Publicado: (2022)

PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation
por: Lee, Sang R., et al.
Publicado: (2023)

A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract
por: Jones, Johanna L., et al.
Publicado: (2021)

Progesterone Can Directly Inhibit the Life Activities of Toxoplasma gondii In Vitro through the Progesterone Receptor Membrane Component (PGRMC)
por: Wu, Yihan, et al.
Publicado: (2022)

Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma
por: Dumitru, Claudia Alexandra, et al.
Publicado: (2023)

A novel progesterone receptor membrane component (PGRMC) in the human and swine parasite Taenia solium: implications to the host-parasite relationship
por: Aguilar-Díaz, Hugo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h2m8db7co4go46aljfcfrm9j4a