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Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer

BACKGROUND: Hyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC). STAT3 is rarely mutated in cancer and the (epi)genetic alterations that lead to STAT3 activation are incompletely understo...

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Detalles Bibliográficos
Autores principales:	Peyser, Noah D., Pendleton, Kelsey, Gooding, William E., Lui, Vivian W. Y., Johnson, Daniel E., Grandis, Jennifer R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113908/ https://www.ncbi.nlm.nih.gov/pubmed/27855189 http://dx.doi.org/10.1371/journal.pone.0166185

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