Cargando…

Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells

Apoptosis is the major downregulated pathway in cancer. Simultaneous inhibition using specific small interfering RNA (siRNA) of two key player genes, p53 and TNF, is an interesting and feasible strategy when it comes to investigating various molecular pathways and biological processes in triple-nega...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pileczki, Valentina, Pop, Laura, Braicu, Cornelia, Budisan, Livia, Bolba Morar, Gabriela, del C Monroig-Bosque, Paloma, Sandulescu, Robert V, Berindan-Neagoe, Ioana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113913/ https://www.ncbi.nlm.nih.gov/pubmed/27956838 http://dx.doi.org/10.2147/OTT.S110719

Ejemplares similares

Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model
por: Braicu, Cornelia, et al.
Publicado: (2015)

TNF-α Gene Knockout in Triple Negative Breast Cancer Cell Line Induces Apoptosis
por: Pileczki, Valentina, et al.
Publicado: (2012)

p53 siRNA - a therapeutic tool with significant implication in the modulation of apoptosis and angiogenic pathways
por: BRAICU, OVIDIU, et al.
Publicado: (2015)

Combining the chemotherapeutic effects of epigallocatechin 3-gallate with siRNA-mediated p53 knock-down results in synergic pro-apoptotic effects
por: Berindan-Neagoe, Ioana, et al.
Publicado: (2012)

Aberrant miRNAs expressed in HER-2 negative breast cancers patient
por: Braicu, Cornelia, et al.
Publicado: (2018)

The added value of CA125, HE4, and CA72-4 as markers for ovarian endometriosis diagnosis
por: Micu, Romeo, et al.
Publicado: (2023)

MicroRNAs as regulators of apoptosis mechanisms in cancer
por: PILECZKI, VALENTINA, et al.
Publicado: (2016)

miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples
por: Braicu, Ovidiu-Leonard, et al.
Publicado: (2017)

Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death
por: Chira, Sergiu, et al.
Publicado: (2018)

Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers
por: Cojocneanu Petric, Roxana, et al.
Publicado: (2015)

A Group of Tumor-Suppressive micro-RNAs Changes Expression Coordinately in Colon Cancer
por: Farc, Ovidiu, et al.
Publicado: (2023)

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
por: Irimie, Alexandra Iulia, et al.
Publicado: (2015)

Effect of Helix aspersa extract on TNFα, NF-κB and some tumor suppressor genes in breast cancer cell line Hs578T
por: El Ouar, Ibtissem, et al.
Publicado: (2017)

Links between Infections, Lung Cancer, and the Immune System
por: Budisan, Liviuta, et al.
Publicado: (2021)

Cellular and Molecular Profiling of Tumor Microenvironment and Early-Stage Lung Cancer
por: Pirlog, Radu, et al.
Publicado: (2022)

Normalization of gene expression measurement of tissue samples obtained by transurethral resection of bladder tumors
por: Pop, Laura A, et al.
Publicado: (2016)

Discovering the Biological Significance and Therapeutic Potential of miR-29b-3p in Triple-Negative Breast Cancer
por: Jurj, Ancuta, et al.
Publicado: (2023)

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
por: Irimie, Alexandra Iulia, et al.
Publicado: (2017)

Identification of Potential microRNA Panels for Male Non-Small Cell Lung Cancer Identification Using Microarray Datasets and Bioinformatics Methods
por: Haranguș, Antonia, et al.
Publicado: (2022)

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer
por: Budisan, Liviuta, et al.
Publicado: (2017)

Serum patterns of mir-23a and mir-181b in irritable bowel syndrome and colorectal cancer - A pilot study
por: Chira, Alexandra, et al.
Publicado: (2020)

Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer
por: Kubelac, Paul, et al.
Publicado: (2021)

Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis
por: Baru, Oana, et al.
Publicado: (2023)

The role of matrix metalloproteinases in patients with pulmonary hypertension: data from a prospective study
por: Marc, Adriana, et al.
Publicado: (2021)

Expression of Selected Genes and Circulating microRNAs in Patients with Celiac Disease
por: Domsa, Elena Maria, et al.
Publicado: (2022)

The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
por: Jurj, Ancuta, et al.
Publicado: (2022)

Investigating Circular RNAs Using qRT-PCR; Roundup of Optimization and Processing Steps
por: Drula, Rares, et al.
Publicado: (2023)

New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells
por: Ciocan-Cartita, Cristina Alexandra, et al.
Publicado: (2020)

Correction to: New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells
por: Ciocan-Cartita, Cristina Alexandra, et al.
Publicado: (2020)

The new era of nanotechnology, an alternative to change cancer treatment
por: Jurj, Ancuta, et al.
Publicado: (2017)

Understanding the Role of Non-Coding RNAs in Bladder Cancer: From Dark Matter to Valuable Therapeutic Targets
por: Pop-Bica, Cecilia, et al.
Publicado: (2017)

Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients
por: Balacescu, Ovidiu, et al.
Publicado: (2016)

Molecular-trapping in Emulsion’s Monolayer: A New Strategy for Production and Purification of Bioactive Saponins
por: Obasi, Titus C., et al.
Publicado: (2017)

TP53 gene implications in prostate cancer evolution: potential role in tumor classification
por: Schitcu, Vlad Horia, et al.
Publicado: (2023)

Dysregulation of miR-21-5p, miR-93-5p, miR-200c-3p and miR-205-5p in Oral Squamous Cell Carcinoma: A Potential Biomarkers Panel?
por: Aghiorghiesei, Ovidiu, et al.
Publicado: (2022)

The Relationships Between Biological Activities and Structure of Flavan-3-Ols
por: Braicu, Cornelia, et al.
Publicado: (2011)

Nanopharmacology in translational hematology and oncology
por: Tomuleasa, Ciprian, et al.
Publicado: (2014)

The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
por: Temian, Daiana Cosmina, et al.
Publicado: (2018)

Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression
por: Braicu, Cornelia, et al.
Publicado: (2019)

Progress in Research on the Role of Flavonoids in Lung Cancer
por: Zanoaga, Oana, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ba12jq7i7hkto2knlm2ap4m7e1