Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling

T lymphocytes require signals from self-peptides and cytokines, most notably interleukins 7 and 15 (IL-7, IL-15), for survival. While mouse T cells die rapidly if IL-7 or IL-15 is withdrawn, human T cells can survive prolonged withdrawal of IL-7 and IL-15. Here we show that IL-7 and IL-15 are requir...

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Detalles Bibliográficos
Autores principales: Drake, Adam, Kaur, Mandeep, Iliopoulou, Bettina P., Phennicie, Ryan, Hanson, Amanda, Chen, Jianzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113943/
https://www.ncbi.nlm.nih.gov/pubmed/27855183
http://dx.doi.org/10.1371/journal.pone.0166280

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