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NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice

PURPOSE: The active form of small GTPase RAC1 is required for activation of NADPH oxidase (NOX), which in turn generates reactive oxygen species (ROS) in nonphagocytic cells. We explored whether NOX-induced oxidative stress contributes to rod degeneration in retinas expressing constitutively active...

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Detalles Bibliográficos
Autores principales:	Song, Hongman, Vijayasarathy, Camasamudram, Zeng, Yong, Marangoni, Dario, Bush, Ronald A., Wu, Zhijian, Sieving, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113981/ https://www.ncbi.nlm.nih.gov/pubmed/27233035 http://dx.doi.org/10.1167/iovs.15-18974

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