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The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei

The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexate and raltitrexed. In conjunction with drug susce...

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Detalles Bibliográficos
Autores principales:	Dewar, Simon, Sienkiewicz, Natasha, Ong, Han B., Wall, Richard J., Horn, David, Fairlamb, Alan H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114424/ https://www.ncbi.nlm.nih.gov/pubmed/27703008 http://dx.doi.org/10.1074/jbc.M116.750422

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