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Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease
This study aimed to investigate changes in resting state brain activity in remissive Crohn’s Disease (CD) patients after electro-acupuncture or moxibustion treatment. Fifty-two CD patients and 36 healthy subjects were enrolled, and 36 patients were equally and randomly assigned to receive either ele...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114555/ https://www.ncbi.nlm.nih.gov/pubmed/27857211 http://dx.doi.org/10.1038/srep36636 |
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author | Bao, Chunhui Liu, Peng Liu, Huirong Jin, Xiaoming Calhoun, Vince D. Wu, Luyi Shi, Yin Zhang, Jianye Zeng, Xiaoqing Ma, Lili Qin, Wei Zhang, Jingzhi Liu, Xiaoming Tian, Jie Wu, Huangan |
author_facet | Bao, Chunhui Liu, Peng Liu, Huirong Jin, Xiaoming Calhoun, Vince D. Wu, Luyi Shi, Yin Zhang, Jianye Zeng, Xiaoqing Ma, Lili Qin, Wei Zhang, Jingzhi Liu, Xiaoming Tian, Jie Wu, Huangan |
author_sort | Bao, Chunhui |
collection | PubMed |
description | This study aimed to investigate changes in resting state brain activity in remissive Crohn’s Disease (CD) patients after electro-acupuncture or moxibustion treatment. Fifty-two CD patients and 36 healthy subjects were enrolled, and 36 patients were equally and randomly assigned to receive either electro-acupuncture or moxibustion treatment for twelve weeks. We used resting state functional magnetic resonance imaging to assess Regional Homogeneity (ReHo) levels, and Crohn’s Disease Activity Index (CDAI) and Inflammatory Bowel Disease Questionnaire (IBDQ) scores to evaluate disease severity and quality of life. The results show that (i) The ReHo levels in CD patients were significantly increased in cortical but decreased in subcortical areas, and the coupling between them was declined. (ii) Both treatments decreased CDAI, increased IBDQ scores, and normalized the ReHo values of the cortical and subcortical regions. (iii) ReHo changes in multiple cortical regions were significantly correlated with CDAI score decreases. ReHo changes in several subcortical regions in the electro-acupuncture group, and those of several cortical regions in the moxibustion group, were correlated with reduced CDAI. These findings suggest that both treatments improved cortex-subcortical coupling in remissive CD patients, but electro-acupuncture regulated homeostatic afferent processing network, while moxibustion mainly regulated the default mode network of the brain. |
format | Online Article Text |
id | pubmed-5114555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51145552016-11-25 Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease Bao, Chunhui Liu, Peng Liu, Huirong Jin, Xiaoming Calhoun, Vince D. Wu, Luyi Shi, Yin Zhang, Jianye Zeng, Xiaoqing Ma, Lili Qin, Wei Zhang, Jingzhi Liu, Xiaoming Tian, Jie Wu, Huangan Sci Rep Article This study aimed to investigate changes in resting state brain activity in remissive Crohn’s Disease (CD) patients after electro-acupuncture or moxibustion treatment. Fifty-two CD patients and 36 healthy subjects were enrolled, and 36 patients were equally and randomly assigned to receive either electro-acupuncture or moxibustion treatment for twelve weeks. We used resting state functional magnetic resonance imaging to assess Regional Homogeneity (ReHo) levels, and Crohn’s Disease Activity Index (CDAI) and Inflammatory Bowel Disease Questionnaire (IBDQ) scores to evaluate disease severity and quality of life. The results show that (i) The ReHo levels in CD patients were significantly increased in cortical but decreased in subcortical areas, and the coupling between them was declined. (ii) Both treatments decreased CDAI, increased IBDQ scores, and normalized the ReHo values of the cortical and subcortical regions. (iii) ReHo changes in multiple cortical regions were significantly correlated with CDAI score decreases. ReHo changes in several subcortical regions in the electro-acupuncture group, and those of several cortical regions in the moxibustion group, were correlated with reduced CDAI. These findings suggest that both treatments improved cortex-subcortical coupling in remissive CD patients, but electro-acupuncture regulated homeostatic afferent processing network, while moxibustion mainly regulated the default mode network of the brain. Nature Publishing Group 2016-11-18 /pmc/articles/PMC5114555/ /pubmed/27857211 http://dx.doi.org/10.1038/srep36636 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Bao, Chunhui Liu, Peng Liu, Huirong Jin, Xiaoming Calhoun, Vince D. Wu, Luyi Shi, Yin Zhang, Jianye Zeng, Xiaoqing Ma, Lili Qin, Wei Zhang, Jingzhi Liu, Xiaoming Tian, Jie Wu, Huangan Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease |
title | Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease |
title_full | Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease |
title_fullStr | Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease |
title_full_unstemmed | Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease |
title_short | Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease |
title_sort | different brain responses to electro-acupuncture and moxibustion treatment in patients with crohn’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114555/ https://www.ncbi.nlm.nih.gov/pubmed/27857211 http://dx.doi.org/10.1038/srep36636 |
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