Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

The nuclear lamina is essential for the proper structure and organization of the nucleus. Deregulation of A‐type lamins can compromise genomic stability, alter chromatin organization and cause premature vascular aging. Here, we show that accumulation of the lamin A precursor, prelamin A, inhibits 53...

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Detalles Bibliográficos
Autores principales: Cobb, Andrew M., Larrieu, Delphine, Warren, Derek T., Liu, Yiwen, Srivastava, Sonal, Smith, Andrew J. O., Bowater, Richard P., Jackson, Stephen P., Shanahan, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114580/
https://www.ncbi.nlm.nih.gov/pubmed/27464478
http://dx.doi.org/10.1111/acel.12506

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