Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming

The CRISPR/Cas9 system is a rapid and customizable tool for gene editing in mammalian cells. In particular, this approach has widely opened new opportunities for genetic studies in neurological disease. Human neurons can be differentiated in vitro from hPSC (human Pluripotent Stem Cells), hNPCs (hum...

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Detalles Bibliográficos
Autores principales: Rubio, Alicia, Luoni, Mirko, Giannelli, Serena G., Radice, Isabella, Iannielli, Angelo, Cancellieri, Cinzia, Di Berardino, Claudia, Regalia, Giulia, Lazzari, Giovanna, Menegon, Andrea, Taverna, Stefano, Broccoli, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114606/
https://www.ncbi.nlm.nih.gov/pubmed/27857203
http://dx.doi.org/10.1038/srep37540

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