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miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer
microRNAs (miRNAs) have emerged as major regulators of the initiation and progression of human cancers, including breast cancer. The aim of this study is to determine the expression pattern of miR-96 in breast cancer and to investigate its biological role during tumorigenesis. We showed that miR-96...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114647/ https://www.ncbi.nlm.nih.gov/pubmed/27857177 http://dx.doi.org/10.1038/srep37421 |
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author | Hong, Yeting Liang, Hongwei Uzair-ur-Rehman, Wang, Yanbo Zhang, Weijie Zhou, Yong Chen, Song’an Yu, Mengchao Cui, Sufang Liu, Minghui Wang, Nan Ye, Chao Zhao, Chihao Liu, Yanqing Fan, Qian Zhang, Chen-Yu Sang, Jianfeng Zen, Ke Chen, Xi |
author_facet | Hong, Yeting Liang, Hongwei Uzair-ur-Rehman, Wang, Yanbo Zhang, Weijie Zhou, Yong Chen, Song’an Yu, Mengchao Cui, Sufang Liu, Minghui Wang, Nan Ye, Chao Zhao, Chihao Liu, Yanqing Fan, Qian Zhang, Chen-Yu Sang, Jianfeng Zen, Ke Chen, Xi |
author_sort | Hong, Yeting |
collection | PubMed |
description | microRNAs (miRNAs) have emerged as major regulators of the initiation and progression of human cancers, including breast cancer. The aim of this study is to determine the expression pattern of miR-96 in breast cancer and to investigate its biological role during tumorigenesis. We showed that miR-96 was significantly upregulated in breast cancer. We then investigated its function and found that miR-96 significantly promoted cell proliferation, migration and invasion in vitro and enhanced tumor growth in vivo. Furthermore, we explored the molecular mechanisms by which miR-96 contributes to breast cancer progression and identified PTPN9 (protein tyrosine phosphatase, non-receptor type 9) as a direct target gene of miR-96. Finally, we showed that PTPN9 had opposite effects to those of miR-96 on breast cancer cells, suggesting that miR-96 may promote breast tumorigenesis by silencing PTPN9. Taken together, this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis. |
format | Online Article Text |
id | pubmed-5114647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51146472016-11-25 miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer Hong, Yeting Liang, Hongwei Uzair-ur-Rehman, Wang, Yanbo Zhang, Weijie Zhou, Yong Chen, Song’an Yu, Mengchao Cui, Sufang Liu, Minghui Wang, Nan Ye, Chao Zhao, Chihao Liu, Yanqing Fan, Qian Zhang, Chen-Yu Sang, Jianfeng Zen, Ke Chen, Xi Sci Rep Article microRNAs (miRNAs) have emerged as major regulators of the initiation and progression of human cancers, including breast cancer. The aim of this study is to determine the expression pattern of miR-96 in breast cancer and to investigate its biological role during tumorigenesis. We showed that miR-96 was significantly upregulated in breast cancer. We then investigated its function and found that miR-96 significantly promoted cell proliferation, migration and invasion in vitro and enhanced tumor growth in vivo. Furthermore, we explored the molecular mechanisms by which miR-96 contributes to breast cancer progression and identified PTPN9 (protein tyrosine phosphatase, non-receptor type 9) as a direct target gene of miR-96. Finally, we showed that PTPN9 had opposite effects to those of miR-96 on breast cancer cells, suggesting that miR-96 may promote breast tumorigenesis by silencing PTPN9. Taken together, this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis. Nature Publishing Group 2016-11-18 /pmc/articles/PMC5114647/ /pubmed/27857177 http://dx.doi.org/10.1038/srep37421 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hong, Yeting Liang, Hongwei Uzair-ur-Rehman, Wang, Yanbo Zhang, Weijie Zhou, Yong Chen, Song’an Yu, Mengchao Cui, Sufang Liu, Minghui Wang, Nan Ye, Chao Zhao, Chihao Liu, Yanqing Fan, Qian Zhang, Chen-Yu Sang, Jianfeng Zen, Ke Chen, Xi miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer |
title | miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer |
title_full | miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer |
title_fullStr | miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer |
title_full_unstemmed | miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer |
title_short | miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer |
title_sort | mir-96 promotes cell proliferation, migration and invasion by targeting ptpn9 in breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114647/ https://www.ncbi.nlm.nih.gov/pubmed/27857177 http://dx.doi.org/10.1038/srep37421 |
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