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Glycation potentiates neurodegeneration in models of Huntington’s disease

Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. By modifying amino-groups, glycation interferes with folding of proteins, increasing their aggregation potential. Here, we studied...

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Detalles Bibliográficos
Autores principales:	Vicente Miranda, Hugo, Gomes, Marcos António, Branco-Santos, Joana, Breda, Carlo, Lázaro, Diana F., Lopes, Luísa Vaqueiro, Herrera, Federico, Giorgini, Flaviano, Outeiro, Tiago Fleming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114697/ https://www.ncbi.nlm.nih.gov/pubmed/27857176 http://dx.doi.org/10.1038/srep36798

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