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Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorpt...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115149/ https://www.ncbi.nlm.nih.gov/pubmed/27440129 http://dx.doi.org/10.21053/ceo.2015.01662 |
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author | Hamed, Mahmood A. Nakata, Seiichi Sayed, Ramadan H. Ueda, Hiromi Badawy, Badawy S. Nishimura, Yoichi Kojima, Takuro Iwata, Noboru Ahmed, Ahmed R. Dahy, Khalid Kondo, Naoki Suzuki, Kenji |
author_facet | Hamed, Mahmood A. Nakata, Seiichi Sayed, Ramadan H. Ueda, Hiromi Badawy, Badawy S. Nishimura, Yoichi Kojima, Takuro Iwata, Noboru Ahmed, Ahmed R. Dahy, Khalid Kondo, Naoki Suzuki, Kenji |
author_sort | Hamed, Mahmood A. |
collection | PubMed |
description | Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications. |
format | Online Article Text |
id | pubmed-5115149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-51151492016-12-01 Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives Hamed, Mahmood A. Nakata, Seiichi Sayed, Ramadan H. Ueda, Hiromi Badawy, Badawy S. Nishimura, Yoichi Kojima, Takuro Iwata, Noboru Ahmed, Ahmed R. Dahy, Khalid Kondo, Naoki Suzuki, Kenji Clin Exp Otorhinolaryngol Review Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications. Korean Society of Otorhinolaryngology-Head and Neck Surgery 2016-12 2016-07-21 /pmc/articles/PMC5115149/ /pubmed/27440129 http://dx.doi.org/10.21053/ceo.2015.01662 Text en Copyright © 2016 by Korean Society of Otorhinolaryngology-Head and Neck Surgery This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Hamed, Mahmood A. Nakata, Seiichi Sayed, Ramadan H. Ueda, Hiromi Badawy, Badawy S. Nishimura, Yoichi Kojima, Takuro Iwata, Noboru Ahmed, Ahmed R. Dahy, Khalid Kondo, Naoki Suzuki, Kenji Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives |
title | Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives |
title_full | Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives |
title_fullStr | Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives |
title_full_unstemmed | Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives |
title_short | Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives |
title_sort | pathogenesis and bone resorption in acquired cholesteatoma: current knowledge and future prospectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115149/ https://www.ncbi.nlm.nih.gov/pubmed/27440129 http://dx.doi.org/10.21053/ceo.2015.01662 |
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