Cargando…

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorpt...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamed, Mahmood A., Nakata, Seiichi, Sayed, Ramadan H., Ueda, Hiromi, Badawy, Badawy S., Nishimura, Yoichi, Kojima, Takuro, Iwata, Noboru, Ahmed, Ahmed R., Dahy, Khalid, Kondo, Naoki, Suzuki, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Otorhinolaryngology-Head and Neck Surgery 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115149/
https://www.ncbi.nlm.nih.gov/pubmed/27440129
http://dx.doi.org/10.21053/ceo.2015.01662
_version_ 1782468474646298624
author Hamed, Mahmood A.
Nakata, Seiichi
Sayed, Ramadan H.
Ueda, Hiromi
Badawy, Badawy S.
Nishimura, Yoichi
Kojima, Takuro
Iwata, Noboru
Ahmed, Ahmed R.
Dahy, Khalid
Kondo, Naoki
Suzuki, Kenji
author_facet Hamed, Mahmood A.
Nakata, Seiichi
Sayed, Ramadan H.
Ueda, Hiromi
Badawy, Badawy S.
Nishimura, Yoichi
Kojima, Takuro
Iwata, Noboru
Ahmed, Ahmed R.
Dahy, Khalid
Kondo, Naoki
Suzuki, Kenji
author_sort Hamed, Mahmood A.
collection PubMed
description Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.
format Online
Article
Text
id pubmed-5115149
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Korean Society of Otorhinolaryngology-Head and Neck Surgery
record_format MEDLINE/PubMed
spelling pubmed-51151492016-12-01 Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives Hamed, Mahmood A. Nakata, Seiichi Sayed, Ramadan H. Ueda, Hiromi Badawy, Badawy S. Nishimura, Yoichi Kojima, Takuro Iwata, Noboru Ahmed, Ahmed R. Dahy, Khalid Kondo, Naoki Suzuki, Kenji Clin Exp Otorhinolaryngol Review Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications. Korean Society of Otorhinolaryngology-Head and Neck Surgery 2016-12 2016-07-21 /pmc/articles/PMC5115149/ /pubmed/27440129 http://dx.doi.org/10.21053/ceo.2015.01662 Text en Copyright © 2016 by Korean Society of Otorhinolaryngology-Head and Neck Surgery This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Hamed, Mahmood A.
Nakata, Seiichi
Sayed, Ramadan H.
Ueda, Hiromi
Badawy, Badawy S.
Nishimura, Yoichi
Kojima, Takuro
Iwata, Noboru
Ahmed, Ahmed R.
Dahy, Khalid
Kondo, Naoki
Suzuki, Kenji
Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
title Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
title_full Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
title_fullStr Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
title_full_unstemmed Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
title_short Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives
title_sort pathogenesis and bone resorption in acquired cholesteatoma: current knowledge and future prospectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115149/
https://www.ncbi.nlm.nih.gov/pubmed/27440129
http://dx.doi.org/10.21053/ceo.2015.01662
work_keys_str_mv AT hamedmahmooda pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT nakataseiichi pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT sayedramadanh pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT uedahiromi pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT badawybadawys pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT nishimurayoichi pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT kojimatakuro pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT iwatanoboru pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT ahmedahmedr pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT dahykhalid pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT kondonaoki pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives
AT suzukikenji pathogenesisandboneresorptioninacquiredcholesteatomacurrentknowledgeandfutureprospectives