A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS‐382 in mouse informs novel therapeutic strategies for the treatment of GHB intoxication

Gamma‐aminobutyric acid (GABA) is an endogenous inhibitory neurotransmitter and precursor of gamma‐hydroxybutyric acid (GHB). NCS‐382 (6,7,8,9‐tetrahydro‐5‐hydroxy‐5H‐benzo‐cyclohept‐6‐ylideneacetic acid), a known GHB receptor antagonist, has shown significant efficacy in a murine model of succinic...

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Detalles Bibliográficos
Autores principales: Ainslie, Garrett R., Gibson, K. Michael, Vogel, Kara R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115179/
https://www.ncbi.nlm.nih.gov/pubmed/27891231
http://dx.doi.org/10.1002/prp2.265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115179/
https://www.ncbi.nlm.nih.gov/pubmed/27891231
http://dx.doi.org/10.1002/prp2.265

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