Cargando…

cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants

Retinal hypoxia and oxidative stress are involved in several retinal degenerations including diabetic retinopathy, glaucoma, central retinal artery occlusion, or retinopathy of prematurity. The second messenger cyclic guanosine monophosphate (cGMP) has been reported to be protective for neuronal cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olivares-González, Lorena, Martínez-Fernández de la Cámara, Cristina, Hervás, David, Marín, María Pilar, Lahoz, Agustin, Millán, José María, Rodrigo, Regina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115799/ https://www.ncbi.nlm.nih.gov/pubmed/27861632 http://dx.doi.org/10.1371/journal.pone.0166717

Ejemplares similares

The cGMP-phosphodiesterase and its contribution to sensitivity regulation in retinal rods
Publicado: (1995)

It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
por: Qureshi, Bilal M., et al.
Publicado: (2018)

Transient kinetics of a cGMP-dependent cGMP-specific phosphodiesterase from Dictyostelium discoideum
Publicado: (1984)

cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
por: Reierson, Gillian W, et al.
Publicado: (2011)

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia
por: Bork, Nadja I., et al.
Publicado: (2021)

In situ cGMP phosphodiesterase and photoreceptor potential in gecko retina
Publicado: (1986)

Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase, alterations in hyperammonemia
por: Monfort, Pilar, et al.
Publicado: (2005)

Elevated retinal cGMP is not associated with elevated circulating cGMP levels in a canine model of retinitis pigmentosa
por: Occelli, Laurence M., et al.
Publicado: (2022)

Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp
por: Turunen, Teemu T., et al.
Publicado: (2019)

Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases
por: Kopra, Kari, et al.
Publicado: (2020)

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
por: Harms, John F., et al.
Publicado: (2019)

Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii
por: Vo, Kim Chi, et al.
Publicado: (2022)

Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina
por: Martínez-Fernández de la Cámara, Cristina, et al.
Publicado: (2014)

cGMP-Phosphodiesterase Inhibition Enhances Photic Responses and Synchronization of the Biological Circadian Clock in Rodents
por: Plano, Santiago A., et al.
Publicado: (2012)

Asymmetric properties of rod cGMP Phosphodiesterase 6 (PDE6): structural and functional analysis
por: Qureshi, Bilal M, et al.
Publicado: (2015)

Phosphodiesterase 9A Controls Nitric-oxide Independent cGMP and Hypertrophic Heart Disease
por: Lee, Dong I., et al.
Publicado: (2015)

Short- and Long-Term Effects of UVA on Arabidopsis Are Mediated by a Novel cGMP Phosphodiesterase
por: Isner, Jean-Charles, et al.
Publicado: (2019)

The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa
por: Maryam, Arooma, et al.
Publicado: (2019)

Blockade of a Retinal cGMP-gated Channel by Polyamines
por: Lu, Zhe, et al.
Publicado: (1999)

Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II
por: Mokni, Walid, et al.
Publicado: (2010)

Angiotensin-(1-7) Downregulates Diabetes-Induced cGMP Phosphodiesterase Activation in Rat Corpus Cavernosum
por: Dhaunsi, Gursev S., et al.
Publicado: (2017)

Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
por: Calamera, Gaia, et al.
Publicado: (2022)

NO/cGMP signalling in platelets
por: Schinner, Elisabeth, et al.
Publicado: (2009)

cGMP and cardiac hypertrophy
por: Perera, Ruwan K, et al.
Publicado: (2015)

Gene therapy approaches to restore retinal cGMP channel function
por: Biel, Martin
Publicado: (2015)

Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors
por: Wen, Lai, et al.
Publicado: (2013)

Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
por: Baliga, Reshma S., et al.
Publicado: (2018)

Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A
por: Taal, Kati, et al.
Publicado: (2019)

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection
por: Foulke-Abel, Jennifer, et al.
Publicado: (2020)

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk
por: Kurelic, Roberta, et al.
Publicado: (2021)

Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology
por: Wolin, Michael S, et al.
Publicado: (2011)

Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
por: Mullershausen, Florian, et al.
Publicado: (2003)

Transducin activates cGMP phosphodiesterase by trapping inhibitory γ subunit freed reversibly from the catalytic subunit in solution
por: Asano, Teizo, et al.
Publicado: (2019)

The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression
por: Dietrich, Peter, et al.
Publicado: (2019)

PDE5 says NO to cGMP
por: LeBrasseur, Nicole
Publicado: (2003)

cGMP steers axons home
por: LeBrasseur, Nicole
Publicado: (2002)

A novel pathway of cGMP
por: Kuhn, Michaela, et al.
Publicado: (2011)

The role of cGMP and PKG in cardioprotection
por: Downey, James M, et al.
Publicado: (2009)

NO-cGMP signalling and cancer therapy
por: Bian, Ka, et al.
Publicado: (2013)

Role of cGMP in fat and metabolism
por: Pfeifer, Alexander, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_r84g99nf1gli79tjnkgkii2a0t