Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

Alu elements are retrotransposons that frequently form new exons during primate evolution. Here, we assess the interplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality control and evolution of new Alu-exons. We identify 3100 new Alu-exons and show that NMD mor...

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Detalles Bibliográficos
Autores principales: Attig, Jan, Ruiz de los Mozos, Igor, Haberman, Nejc, Wang, Zhen, Emmett, Warren, Zarnack, Kathi, König, Julian, Ule, Jernej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115870/
https://www.ncbi.nlm.nih.gov/pubmed/27861119
http://dx.doi.org/10.7554/eLife.19545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115870/
https://www.ncbi.nlm.nih.gov/pubmed/27861119
http://dx.doi.org/10.7554/eLife.19545

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