The role of hydrogen sulfide in aging and age-related pathologies

When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the ‘hallmark...

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Detalles Bibliográficos
Autores principales: Perridon, Bernard W., Leuvenink, Henri G.D., Hillebrands, Jan-Luuk, van Goor, Harry, Bos, Eelke M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115888/
https://www.ncbi.nlm.nih.gov/pubmed/27683311
http://dx.doi.org/10.18632/aging.101026
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author Perridon, Bernard W.
Leuvenink, Henri G.D.
Hillebrands, Jan-Luuk
van Goor, Harry
Bos, Eelke M.
author_facet Perridon, Bernard W.
Leuvenink, Henri G.D.
Hillebrands, Jan-Luuk
van Goor, Harry
Bos, Eelke M.
author_sort Perridon, Bernard W.
collection PubMed
description When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the ‘hallmarks of aging’. These hallmarks describe (patho-)physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H(2)S) in the regulation of aging. Nowadays, H(2)S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H(2)S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies.
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spelling pubmed-51158882016-11-29 The role of hydrogen sulfide in aging and age-related pathologies Perridon, Bernard W. Leuvenink, Henri G.D. Hillebrands, Jan-Luuk van Goor, Harry Bos, Eelke M. Aging (Albany NY) Review When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the ‘hallmarks of aging’. These hallmarks describe (patho-)physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H(2)S) in the regulation of aging. Nowadays, H(2)S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H(2)S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies. Impact Journals LLC 2016-09-27 /pmc/articles/PMC5115888/ /pubmed/27683311 http://dx.doi.org/10.18632/aging.101026 Text en Copyright: © 2016 Perridon et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Perridon, Bernard W.
Leuvenink, Henri G.D.
Hillebrands, Jan-Luuk
van Goor, Harry
Bos, Eelke M.
The role of hydrogen sulfide in aging and age-related pathologies
title The role of hydrogen sulfide in aging and age-related pathologies
title_full The role of hydrogen sulfide in aging and age-related pathologies
title_fullStr The role of hydrogen sulfide in aging and age-related pathologies
title_full_unstemmed The role of hydrogen sulfide in aging and age-related pathologies
title_short The role of hydrogen sulfide in aging and age-related pathologies
title_sort role of hydrogen sulfide in aging and age-related pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115888/
https://www.ncbi.nlm.nih.gov/pubmed/27683311
http://dx.doi.org/10.18632/aging.101026
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