Design, Synthesis and Microbiological Evaluation of Ampicillin Tetramic acid Hybrid Antibiotics

Exploiting iron-uptake pathways by conjugating β-lactam antibiotics with iron-chelators such as catechol and hydroxamic acid is a proven strategy to overcome permeability-related resistance in Gram-negative bacteria. Since naturally occurring iron chelating tetramic acids have not been previously ex...

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Detalles Bibliográficos
Autores principales: Cherian, Philip T., Deshpande, Aditi, Cheramie, Martin N., Bruhn, David F., Hurdle, Julian G., Lee, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116011/
https://www.ncbi.nlm.nih.gov/pubmed/27189120
http://dx.doi.org/10.1038/ja.2016.52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116011/
https://www.ncbi.nlm.nih.gov/pubmed/27189120
http://dx.doi.org/10.1038/ja.2016.52

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