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Design, Synthesis and Microbiological Evaluation of Ampicillin Tetramic acid Hybrid Antibiotics
Exploiting iron-uptake pathways by conjugating β-lactam antibiotics with iron-chelators such as catechol and hydroxamic acid is a proven strategy to overcome permeability-related resistance in Gram-negative bacteria. Since naturally occurring iron chelating tetramic acids have not been previously ex...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116011/ https://www.ncbi.nlm.nih.gov/pubmed/27189120 http://dx.doi.org/10.1038/ja.2016.52 |