Cargando…
Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues
Contamination of retrieved tissues is a major problem for allograft safety. Consequently, tissue banks have implemented decontamination protocols to eliminate microorganisms from tissues. Despite the widespread adoption of these protocols, few comprehensive studies validating such methods have been...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116045/ https://www.ncbi.nlm.nih.gov/pubmed/27604467 http://dx.doi.org/10.1007/s10561-016-9581-6 |
_version_ | 1782468601291210752 |
---|---|
author | Serafini, Agnese Riello, Erika Trojan, Diletta Cogliati, Elisa Palù, Giorgio Manganelli, Riccardo Paolin, Adolfo |
author_facet | Serafini, Agnese Riello, Erika Trojan, Diletta Cogliati, Elisa Palù, Giorgio Manganelli, Riccardo Paolin, Adolfo |
author_sort | Serafini, Agnese |
collection | PubMed |
description | Contamination of retrieved tissues is a major problem for allograft safety. Consequently, tissue banks have implemented decontamination protocols to eliminate microorganisms from tissues. Despite the widespread adoption of these protocols, few comprehensive studies validating such methods have been published. In this manuscript we compare the bactericidal activity of different antibiotic cocktails at different temperatures against a panel of bacterial species frequently isolated in allograft tissues collected at the Treviso Tissue Bank Foundation, a reference organization of the Veneto Region in Italy that was instituted to select, recover, process, store and distribute human tissues. We were able to identify at least two different formulations capable of killing most of the bacteria during prolonged incubation at 4 °C. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10561-016-9581-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5116045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-51160452016-12-02 Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues Serafini, Agnese Riello, Erika Trojan, Diletta Cogliati, Elisa Palù, Giorgio Manganelli, Riccardo Paolin, Adolfo Cell Tissue Bank Article Contamination of retrieved tissues is a major problem for allograft safety. Consequently, tissue banks have implemented decontamination protocols to eliminate microorganisms from tissues. Despite the widespread adoption of these protocols, few comprehensive studies validating such methods have been published. In this manuscript we compare the bactericidal activity of different antibiotic cocktails at different temperatures against a panel of bacterial species frequently isolated in allograft tissues collected at the Treviso Tissue Bank Foundation, a reference organization of the Veneto Region in Italy that was instituted to select, recover, process, store and distribute human tissues. We were able to identify at least two different formulations capable of killing most of the bacteria during prolonged incubation at 4 °C. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10561-016-9581-6) contains supplementary material, which is available to authorized users. Springer Netherlands 2016-09-07 2016 /pmc/articles/PMC5116045/ /pubmed/27604467 http://dx.doi.org/10.1007/s10561-016-9581-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Serafini, Agnese Riello, Erika Trojan, Diletta Cogliati, Elisa Palù, Giorgio Manganelli, Riccardo Paolin, Adolfo Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
title | Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
title_full | Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
title_fullStr | Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
title_full_unstemmed | Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
title_short | Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
title_sort | evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116045/ https://www.ncbi.nlm.nih.gov/pubmed/27604467 http://dx.doi.org/10.1007/s10561-016-9581-6 |
work_keys_str_mv | AT serafiniagnese evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues AT rielloerika evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues AT trojandiletta evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues AT cogliatielisa evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues AT palugiorgio evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues AT manganelliriccardo evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues AT paolinadolfo evaluationofnewantibioticcocktailsagainstcontaminatingbacteriafoundinallografttissues |