Cargando…
Microbe-mediated host defence drives the evolution of reduced pathogen virulence
Microbes that protect their hosts from pathogens are widespread in nature and are attractive disease control agents. Given that pathogen adaptation to barriers against infection can drive changes in pathogen virulence, ‘defensive microbes' may shape disease severity. Here we show that co-evolvi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116080/ https://www.ncbi.nlm.nih.gov/pubmed/27845328 http://dx.doi.org/10.1038/ncomms13430 |
_version_ | 1782468608296747008 |
---|---|
author | Ford, Suzanne A. Kao, Damian Williams, David King, Kayla C. |
author_facet | Ford, Suzanne A. Kao, Damian Williams, David King, Kayla C. |
author_sort | Ford, Suzanne A. |
collection | PubMed |
description | Microbes that protect their hosts from pathogens are widespread in nature and are attractive disease control agents. Given that pathogen adaptation to barriers against infection can drive changes in pathogen virulence, ‘defensive microbes' may shape disease severity. Here we show that co-evolving a microbe with host-protective properties (Enterococcus faecalis) and a pathogen (Staphylococcus aureus) within Caenorhabditis elegans hosts drives the evolution of reduced pathogen virulence as a by-product of adaptation to the defensive microbe. Using both genomic and phenotypic analyses, we discover that the production of fewer iron-scavenging siderophores by the pathogen reduces the fitness of the defensive microbe and underpins the decline in pathogen virulence. These data show that defensive microbes can shape the evolution of pathogen virulence and that the mechanism of pathogen resistance can determine the direction of virulence evolution. |
format | Online Article Text |
id | pubmed-5116080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51160802017-01-13 Microbe-mediated host defence drives the evolution of reduced pathogen virulence Ford, Suzanne A. Kao, Damian Williams, David King, Kayla C. Nat Commun Article Microbes that protect their hosts from pathogens are widespread in nature and are attractive disease control agents. Given that pathogen adaptation to barriers against infection can drive changes in pathogen virulence, ‘defensive microbes' may shape disease severity. Here we show that co-evolving a microbe with host-protective properties (Enterococcus faecalis) and a pathogen (Staphylococcus aureus) within Caenorhabditis elegans hosts drives the evolution of reduced pathogen virulence as a by-product of adaptation to the defensive microbe. Using both genomic and phenotypic analyses, we discover that the production of fewer iron-scavenging siderophores by the pathogen reduces the fitness of the defensive microbe and underpins the decline in pathogen virulence. These data show that defensive microbes can shape the evolution of pathogen virulence and that the mechanism of pathogen resistance can determine the direction of virulence evolution. Nature Publishing Group 2016-11-15 /pmc/articles/PMC5116080/ /pubmed/27845328 http://dx.doi.org/10.1038/ncomms13430 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Ford, Suzanne A. Kao, Damian Williams, David King, Kayla C. Microbe-mediated host defence drives the evolution of reduced pathogen virulence |
title | Microbe-mediated host defence drives the evolution of reduced pathogen virulence |
title_full | Microbe-mediated host defence drives the evolution of reduced pathogen virulence |
title_fullStr | Microbe-mediated host defence drives the evolution of reduced pathogen virulence |
title_full_unstemmed | Microbe-mediated host defence drives the evolution of reduced pathogen virulence |
title_short | Microbe-mediated host defence drives the evolution of reduced pathogen virulence |
title_sort | microbe-mediated host defence drives the evolution of reduced pathogen virulence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116080/ https://www.ncbi.nlm.nih.gov/pubmed/27845328 http://dx.doi.org/10.1038/ncomms13430 |
work_keys_str_mv | AT fordsuzannea microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence AT kaodamian microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence AT williamsdavid microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence AT kingkaylac microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence |