Cargando…

Microbe-mediated host defence drives the evolution of reduced pathogen virulence

Microbes that protect their hosts from pathogens are widespread in nature and are attractive disease control agents. Given that pathogen adaptation to barriers against infection can drive changes in pathogen virulence, ‘defensive microbes' may shape disease severity. Here we show that co-evolvi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ford, Suzanne A., Kao, Damian, Williams, David, King, Kayla C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116080/
https://www.ncbi.nlm.nih.gov/pubmed/27845328
http://dx.doi.org/10.1038/ncomms13430
_version_ 1782468608296747008
author Ford, Suzanne A.
Kao, Damian
Williams, David
King, Kayla C.
author_facet Ford, Suzanne A.
Kao, Damian
Williams, David
King, Kayla C.
author_sort Ford, Suzanne A.
collection PubMed
description Microbes that protect their hosts from pathogens are widespread in nature and are attractive disease control agents. Given that pathogen adaptation to barriers against infection can drive changes in pathogen virulence, ‘defensive microbes' may shape disease severity. Here we show that co-evolving a microbe with host-protective properties (Enterococcus faecalis) and a pathogen (Staphylococcus aureus) within Caenorhabditis elegans hosts drives the evolution of reduced pathogen virulence as a by-product of adaptation to the defensive microbe. Using both genomic and phenotypic analyses, we discover that the production of fewer iron-scavenging siderophores by the pathogen reduces the fitness of the defensive microbe and underpins the decline in pathogen virulence. These data show that defensive microbes can shape the evolution of pathogen virulence and that the mechanism of pathogen resistance can determine the direction of virulence evolution.
format Online
Article
Text
id pubmed-5116080
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-51160802017-01-13 Microbe-mediated host defence drives the evolution of reduced pathogen virulence Ford, Suzanne A. Kao, Damian Williams, David King, Kayla C. Nat Commun Article Microbes that protect their hosts from pathogens are widespread in nature and are attractive disease control agents. Given that pathogen adaptation to barriers against infection can drive changes in pathogen virulence, ‘defensive microbes' may shape disease severity. Here we show that co-evolving a microbe with host-protective properties (Enterococcus faecalis) and a pathogen (Staphylococcus aureus) within Caenorhabditis elegans hosts drives the evolution of reduced pathogen virulence as a by-product of adaptation to the defensive microbe. Using both genomic and phenotypic analyses, we discover that the production of fewer iron-scavenging siderophores by the pathogen reduces the fitness of the defensive microbe and underpins the decline in pathogen virulence. These data show that defensive microbes can shape the evolution of pathogen virulence and that the mechanism of pathogen resistance can determine the direction of virulence evolution. Nature Publishing Group 2016-11-15 /pmc/articles/PMC5116080/ /pubmed/27845328 http://dx.doi.org/10.1038/ncomms13430 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ford, Suzanne A.
Kao, Damian
Williams, David
King, Kayla C.
Microbe-mediated host defence drives the evolution of reduced pathogen virulence
title Microbe-mediated host defence drives the evolution of reduced pathogen virulence
title_full Microbe-mediated host defence drives the evolution of reduced pathogen virulence
title_fullStr Microbe-mediated host defence drives the evolution of reduced pathogen virulence
title_full_unstemmed Microbe-mediated host defence drives the evolution of reduced pathogen virulence
title_short Microbe-mediated host defence drives the evolution of reduced pathogen virulence
title_sort microbe-mediated host defence drives the evolution of reduced pathogen virulence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116080/
https://www.ncbi.nlm.nih.gov/pubmed/27845328
http://dx.doi.org/10.1038/ncomms13430
work_keys_str_mv AT fordsuzannea microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence
AT kaodamian microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence
AT williamsdavid microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence
AT kingkaylac microbemediatedhostdefencedrivestheevolutionofreducedpathogenvirulence