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17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular mechanisms by which these variants perturb gene expression and the cell types in which this effect is most prominent are uncle...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116091/ https://www.ncbi.nlm.nih.gov/pubmed/27848966 http://dx.doi.org/10.1038/ncomms13426 |